9/4th MLC lecture

Question 0

mechanism:

How antiphospholipid AB syndrome induces thrombosis….

Answer 0

1. interfere w/ endogenous anticoagulants
2. Binding and activation of platelets
3. interact w/ endothelial cells and induce the expression of adhesion molecules and TF
4. Activation of the complement cascade??? - but there is no classic inflammation so this is questionable!

Question 1

Criteria for antiphospholipid AB syndrome

Answer 1

1 of the vascular/pregnancy criteria and one lab criteria.
1st criteria options:

1. Vascular thrombosis,
2. unexpected death of fetus at or beyond 10th week,
3. 1 or more premature births before 34th wk,
4. 3 or more consecutive spontaneous abortions.

and 1 of the following:

1. lupus anticoag
2. Anticardiolipin IgM or IgG.** will be false +ve for syphilis in lupus pts, coz syphilis has an anticardiolip AB** .. This is also assoc. with high risk of thrombosis.
3. Anti Beta 2- glycoprotein-1 ABs of IgG and or IgM isotype