9/22- Pharmacology of Obstructive Lung Diseases Flashcards
What are the main pathologic features in obstructive lung diseases?
- Bronchoconstriction
- Increased airway inflammation
- Increased mucus production
- Airway Remodeling
- Parenchymal lung destruction (emphysema)
Describe PS bronchial autonomic innervation
- NT
- Mechanism
- End result
Parasympathetic
- NT: ACh
- Binds muscarinic M3 receptors (cholinergic) on sm cells within bronchial walls
- End result: constricts the airways
Describe sympathetic bronchial autonomic innervation
- NT
- Mechanism
- End result
- NT: catecholamines
- Binds adrenergic receptors
- Airway sm cells express B2 adrenergic receps mainly (expressed elsewhere too, but mostly on smooth muscles)
- End result: bronchodilation
Overview of Medications for Asthma - Ant-inflammatories - Bronchodilators - Others
Anti-inflammatories:
- Inhaled Corticosteroids
- Antileukotrienes
- Cromones
- Theophylline (?)
Bronchodilators
- Short and Long-acting ß-agonists
- Short-acting Anticholinergic ICS/LABA
Combination
Anti IgE
(Thus, you can see that bronchodilation may be achieved by promoting sympathetic stimulation or blocking PS)
Overview of Medications for COPD:
- Ant-inflammatories
- Bronchodilators
- Others
Anti-inflammatories:
- Inhaled Corticosteroids
- Roflumilast Bronchodilators
- Short and Long-acting ß-agonists
- Short and Long-acting
Anticholinergics
- Theophylline
What method of administration is preferred for bronchodilators?
Inhalation
- Can be given systemically if really severe/can’t inhale
What is the benefit of combining bronchodilators in COPD?
- May improve efficacy
- May decrease the risk of side effects compared with increasing the dose of a single bronchodilator
Provide examples of classes of bronchodilators?
- Beta 2 agonists
- Anticholinergics
- Methylxanthines
How do the following effect bronchodilation?
- Beta agonists
- Muscarinic antagonists
- Theophylline
- Beta agonists: activation of AC -> more cAMP -> bronchodilation
- Muscarinic antagonists: block ACh activation of bronchoconstriction
- Theophylline: blocks PDE, increasing cAMP levels (by preventing cAMP -> AMP degradation) and blocks adenosine (?)
In addition to relaxing airway sm, what other functions to B2 agonists have?
- Inhibition of plasma exudation and airway edema
- No effect on chronic inflammation
- Don’t want too use to frequently (bad outcomes), so used to supplement long-acting treatment
Provide example drugs for short and long-acting B2 agonists?
(Don’t need to remember drug names at this point)
Short
- Albuterol
- Pirbuterol
Long
- Salmeterol
- Formoterol
- Indacaterol
Describe short-acting beta agonists
- Onset
- Duration
- Frequency
(Albuterol is the most commonly used rescue inhaler)
- Onset: rapid, within 10-15 min
- Duration: max 4-6 hrs
- Most effective when used on “as-needed” basis, or “rescue”
Describe long-acting beta agonists
- Duration
- Frequency
- Effects
(Salmeterol and formoterol)
- Similar to short-acting, but longer duration: 12 hrs
- Dosed 2x/day
- Variable effects on exercise, exacerbation, QOL
- Should only be used as add-on to ICS (immunocorticosteroids?) in asthma
Recommendations on use of LABAs in Asthma?
Not recommended as monotherapy for long-term control
- Consider as adjunctive therapy in patients aged >5 years who require more than a low-dose ICS
- Consider adding an LTRA in patients aged >5 years
Not recommended for treatment of acute symptoms
May be used before exercise to prevent EIB
How to anticholinergics function to alleviate asthma and COPD (mechanism/targeted pathology)?
- Block vagal pathways-decreases vagal tone
- Blocks reflex bronchoconstriction caused by inhaled irritants
- Role in asthma is less clear (than in COPD) may have added benefit in combination with beta2-agonists in acute asthma
- Delivered locally, but may be associated with systemic effects (since cholinergic): most common = dry mouth
Provide examples of short and long acting anticholinergics (don’t memorize names)?
- Ipratropium: slow onset (30 min)
- Tiotropium: bronchodilation, long acting (24 hrs)
Overall, slower than B2 agonists, which is why the latter are preferred in rescue situations
What drug is included in the class of methylxanthines?
Theophylline
Describe Theophylline
- Functions
- Mechanism
- Duration
- Dosing
- Metabolism
- Toxicity
- Bronchodilator (mild-moderate) with questionable anti-inflammatory properties
- Mechanism uncertain (probably PDE inhibition)
- Long acting dosage form
- Very narrow therapeutic window (get ASEs easily!)
- Recommended serum concentration = 5-8 ug/mL; dose varies person to preson
- Metabolism: liver
Toxicity:
- GI (most common): irritation, burning, nausea
- CNS stimulation: tremors
- Tachyardia