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ANKI Rheumatology > [8] Systemic Lupus Erythematosus > Flashcards

[8] Systemic Lupus Erythematosus Flashcards

1
Q

What is SLE?

A

A multi-systemic autoimmune inflammatory disease in which auto-antibodies to a variety of autoantigens result in the formation and deposition of immune complexes

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2
Q

What is the prevalence of SLE?

A

0.2%

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3
Q

What is the male:female ratio of SLE?

A

M:F = 1:9

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4
Q

What age does SLE present?

A

Child bearing age

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5
Q

Which ethnicity has a higher incidence of SLE?

A

Afro-caribbeans and Asians

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6
Q

What course does SLE take?

A

Relaxing and remitting

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7
Q

What constitutional symptoms are present in SLE?

A

Fatigue
Weight loss
Fever
Myalgia

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8
Q

What are the categories of clinical features of SLE?

A 
Renal
Serosal
Haemotological 
Immune
Neurological
Other
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9
Q

What are the other symptoms of SLE?

A

Arthritis
Photosensitivity
Oral ulcers
Rash

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10
Q

Describe the arthritis in SLE

A

Non-erosive

Involving peripheral joints

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11
Q

What arthritic condition might develop in SLE?

A

Jaccourd’s arthritis

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12
Q

What is Jaccourd’s arthritis?

A

A reducible deforming arthropathy

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13
Q

What are the renal features of SLE?

A

Proteinuria

Increased BP

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14
Q

What are the serosal features of SLE?

A

Pleuritis

Pericarditis

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15
Q

What are the features of pleuritis in SLE?

A

Pleuritic pain
Dyspnoea
Effusions

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16
Q

What are the symptoms of pericarditis in SLE?

A

Chest pain relieved by sitting forwards

17
Q

What are the haemotological features of SLE?

A

Autoimmune haemolytic anaemia
Decreased WCC
Decreased platelets

18
Q

What are the immune features of SLE?

A

Anti-dsDNA antibodies
Anti-Sm antibodies
Anti-phospholipid antibodies

19
Q

What are the neurological features of SLE?

A

Seizures

Psychosis

20
Q

What rash might develop in SLE?

A

Malar rash

Discoid rash

21
Q

What is a malar rash?

A

Facial erythema sparing the nasolabial folds

22
Q

What happens in a discoid rash?

A

Erythema leads to pigmented hyperkeratotic papules, leading to atrophic depressed lesions

23
Q

Where does the discoid rash affect in SLE?

A

Mainly the face and chest

24
Q

What % of cases of SLE are ANA +ve?

A

95%

25
Q

What immunology test is very specific for SLE?

A

dsDNA

26
Q

What is the sensitivity of dsDNA test for SLE?

A

60%

27
Q

What % of cases of SLE are ENA +ve?

A

30%

28
Q

How is disease activity monitored in SLE?

A

Ant-dsDNA titres
Complement
ESR

29
Q

What happens to complement in SLE?

A

Decreased C3 and C4

30
Q

What happens to ESR in SLE?

A

Increases

31
Q

What other investigations should be done in SLE?

A

Bloods

Urine

32
Q

What blood tests should be done in SLE?

A

FBC
U&E
CRP
Clotting

33
Q

What urine tests should be done in SLE?

A

Dipstick

PCR

34
Q

Where should SLE be managed?

A

In specialist SLE and lupus nephritis clinics

ANKI Rheumatology (14 decks)

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