8 steps Flashcards
What is a mnemonic for Krebs?
Can I Keep Selling Sex For Money, Officer?
1st step - (Can)
Citrate is form from acetyl CoA and oxaloacetate.
What is the enzyme for step 1?
Citrate synthase
What inhibits citrate synthase?
ATP!
2nd Step (I)
Isocitrate is produced from citrate
Enzyme for step 2?
aconitase
Step 3 - (Keep)
alpha-ketoglutarate is produce from isocitrate
Enzyme used in Step 3?
Isocitrate dehydrogenase
What is the rate limiting enzyme in Krebs?
Isocitrate dehydrogenase (step 3)
What activates isocitrate dehydrogenase?
ADP
What inhibits isocitrate dehydrogenase?
ATP and NADH
One ______ is produced in the 3rd step.
NADH
One molecule of what is released in the 3rd step.
CO2
4th step (Selling)
succinyl CoA is produced from alpha-ketoglutarate
What enzyme is used in 4th step?
alpha-ketoglutarate dehydrogenase
What doe alpha-ketoglutarate require?
Vitamin B1 - thiamine
Vitamin B2 - riboflavin
Vitamin B3 - Niacin
Vitamin B5 - Pantothenic Acid
What molecule is produced and what molecule is released in step 4?
One NADH
one CO2
Step 5 (Sex)
Succinct is produced from succinyl CoA
What enzyme catalyzed step 5 reaction?
Succinct thiokinase aka succinyl CoA synthetase
One high energy ____ is produce in step 5.
GTP
GTP can react with what? To make what?
ADP
ATP
6th Step: (For)
fumarate is produce from succinate
What is enzyme for step 6?
Succinate dehydrogenase
What is the only TCA cycle enzyme bound to the mitochondrial membrane instead of being soluble in the mitochondrial matrix?
succinate dehydrogenase