8 - Radiation Safety Flashcards
Radiobiology
- The effects of ionizing radiation on biologic tissue
- Not known whether there are effects from diagnostic x-rays
- Always use lowest permissible dose
What are the two human responses to ionizing radiation?
- Stochastic effects
- Deterministic (non-stochastic) effects
Stochastic effects
Stochastic effects: responses where probability of occurrence increases with dose; ie, the higher the dose, the greater the chance of effects
Deterministic (nonstochastic) effects
Deterministic (nonstochastic) effects: severity of response increases with dose; i.e., the higher the dose, the more severe the response
Describe when we see stochastic effects
** KNOW FOR EXAM **
- Do not have a threshold dose and are observed for months or years ***
- Result from low radiation doses over a long time ***
- Include leukemia, bone, breast and lung CA
- Include radiodermatitis and cataracts
- Infant exposure produces 4x the cancer risk of adults
Describe when we see deterministic (non-stochastic) effects
** KNOW FOR EXAM **
- Have threshold dose which needs to be exceeded before response is seen and severity of response proportional to dose ***
- Occur early within minutes or days ***
- Radiation sickness causes death to hematologic, GI, and nervous systems ***
- Skin desquamates, ovaries and testes atrophy and become sterile
- Prenatal and neonatal death, congenital malformation, childhood malignancy, diminished growth
Matching REVIEW
** KNOW FOR EXAM **
1 - Cataracts…
2 - Radiation sickness…
3 - Occurs in hours to days…
4 - Occurs in years…
1 - Cataracts… Stochastic effects
2 - Radiation sickness… Non-stochastic effects
3 - Occurs in hours to days… Non-stochastic effects
4 - Occurs in years… Stochastic effects
Effects of ionizing radiation on tissues
Law of Bergonie and Tribondeau
- Sensitivity of tissues depends upon proliferative capacity (rapidly dividing cells more sensitive than slowly dividing cells) and differentiation (fully differentiated cells less sensitive
- Most sensitive: bone marrow>lymphocytes>GI
- Most resistant: CNS
4 physical factors affecting radiosensitivity
- Linear energy transfer (LET)
- Relative biologic effectiveness
- Protraction
- Fractionation
Linear energy transfer (LET)
Measure of amount of energy transferred along path of radiation
- Low: x-rays
- Medium: photons
- High: alpha particles (cause direct tissue damage)
Relative biologic effectiveness
Effectiveness of one form of radiation compared to another
Protraction
Radiation dose to neoplasm is delivered continuously, but at a lower dose rate
CONTINUOUS LOW DOSE
Fractionation
Same radiation dose rate to neoplasm is delivered in equal fractions, each separated by period of time
SEPARATE BOLUS DOSES
Biologic factors affecting radiosensitivity
- Tissues more sensitive when irradiated in the oxygenated state
- Utero and old age most sensitive
- Males more sensitive than females
- Cell is capable of recovery if it is not killed before next division
- Molecules with sulfhydryl group are radioprotective
- Vitamin K, methotrexate, actinomycin D are radiosensitizers
Matching REVIEW
** KNOW FOR EXAM **
More or less sensitive to radiation?
- Oxygenated tissues
- Molecules with sulfydryl group
- Adolescents
- Seniors
- CNS
- Bone marrow
More or less sensitive to radiation?
- Oxygenated tissues (MORE)
- Molecules with sulfydryl group (LESS)
- Adolescents (LESS)
- Seniors (MORE)
- CNS (LESS)
- Bone marrow (MORE)
Types of radiation dose-response relationships
- Linear nonthreshold
- Linear threshold
- Nonlinear nonthreshold
- Linear nonthreshold
Linear dose-response
Linear: response directly proportional to dose
Nonlinear dose-response
Nonlinear: response not directly proportional
Threshold dose-response
Threshold: no response produced at a dose below the theshold dose
Nonthreshold dose-response
Nonthreshold: any size dose is expected to produce a response
Irradiation of macrocolecules
- High doses of radiation kill cells immediately (you see sloughing off and dying skin right away)
- Low doses of radiation causes DNA damage (this results in defects over time)
Direct effects of radiation
- Radiation interacts directly with a molecule like DNA
- Accounts for small fraction of damage at low LET, but most of damage at high LET
Indirect effects of radiation
- Caused by free radicals formed from ionizing radiation interacting with body and associated with radiolysis of water
- Free radicals migrate from the initial site of ionization of DNA, transfers its excess energy and disrupts bonds
- Accounts for most damage at low LET
Matching REVIEW
** KNOW THIS **
1 - Response directly proportional to dose and any dose produces effects…
2 - Response not dependent upon dose, but no response will be seen if threshold dose not exceeded…
3 - Direct radiation effects…
4 - Non-direct radiation effects…
1 - Response directly proportional to dose and any dose produces effects… Linear nonthreshold
2 - Response not dependent upon dose, but no response will be seen if threshold dose not exceeded… Nonlinear threshold
3 - Direct radiation effects… Direct DNA damage
4 - Non-direct radiation effects… Free radical formation