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Fa: Pharm 3 > 8. Obesity > Flashcards

8. Obesity Flashcards

1
Q

obesity is associated with

A

incr morbidity and mortality

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2
Q

short term pharmacologic obesity treatment

A

phentermine
benzphetamine
diethylproprion
phendimetrazine

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3
Q

long term pharmacologic obesity treatment

A

orlistat
naltrexone/bupropion
liraglutide
semaglutide
tirzepatide

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4
Q

obesity

A

abnormally high amount of adipose tissue compared with lean muscle mass

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5
Q

obesity is what % over ideal body weight

A

> = 20 %

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6
Q

direct measures of body comp

A

underwater weighting
skin fold measurement
BIA
DEXA

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7
Q

indirect measures of body comp

A

BMI
BSA
IBW
LBW
PNWT

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8
Q

overweight BMI

A

25-29.9

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9
Q

class 1 obesity

A

30-34.9

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10
Q

class 2 obesity

A

35-39.9

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11
Q

class 3 obesity

A

> =40

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12
Q

LBW =

A

TBW - fat weight

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13
Q

LBW compared to IDW

A

LBW > IDW

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14
Q

LBW ~

A

LBW ~ 1.3*IBW

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15
Q

obesity oral abs

A

unchanged

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16
Q

obesity transderma/subQ absorption

A

decr subQ abs

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17
Q

obesity Vd

A

incr Vd for lipophillic drugs

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18
Q

hydrophylic drugs in obese pts

A

little change in Vd

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19
Q

hepatic blood flow in obesity

A

increased hepatic blood flow

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20
Q

what does incr hepatic blood flow mean

A

incr clearance of high extraction ratio drugs

21
Q

high extraction ratio drugs

A

propofol
ketamine
morphine

22
Q

obesity drug half life

A

incr half life due to incr Vd for lipophillic drugs

23
Q

hydrophillic drug clearance

A

incr renal clearance

24
Q

risk of failed regional block

A

1.5* higher when BMI > 30

25
Q

obese pts spinal/epidural dosing

A

20% less local anesthetic

26
Q

VA lipophiliciity

A

HIGH
iso
sevo
des
LOW

27
Q

which VA is not commonly used in obesity

A

iso

28
Q

which VA is recommended in obese pts

A

des

29
Q

sux dosing obesity

A

TBW

30
Q

vecuronium
cisatracurium dosing obesity

A

IBW
LBW

31
Q

roc dosing obesity

A

IBW
LBW

32
Q

pancuronium dosing obesity

A

higher doses needed

33
Q

best reversal agent for obesity

A

sugammadex

34
Q

sugammadex obesity dosing

A

TBW
IBW+40%

35
Q

thipental induction dose

A

LBW

36
Q

thiopental mx dose

A

TBW

37
Q

dexmedetomidine dose

A

LBW
IBW

38
Q

propofol induction dose

A

LBW

39
Q

propofol mx dose

A

TBW

40
Q

etomidate dose

A

LBW

41
Q

fentanyl dose

A

LBW

42
Q

most highly lipopphilic opioid

A

sufentanil

43
Q

sufentanil dosing si

A

unpredicatble

44
Q

remi dosing

A

IBW
LBM

45
Q

obesitiy is a ________ for VTE

A

independent risk factor for VTE

46
Q

all obese pts should receive

A

VTE prophylaxis

47
Q

VTE prophylaxis

A

SCDs
inferior vena cava filters
LMWH
fondaparinux

48
Q

low VTE risk

A

LMWH
or IPC

49
Q

high VTE risk

A

LMWH
and IPC

Fa: Pharm 3 (10 decks)

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