8. Guillain-Barré Syndrome Flashcards
Clinical features
- Prodrome
Camplybacter jej / myocplasma pneumoniae / cmv / ebv / vaccine / major surgery
Progressing ascending
symetrical limb weakness
distal paraesthesia / pain / sensory loss
Reduced / absent reflexes
Nerve Palsies
FN/bulbar nerve
Respiratory muscle involvement
ultimately may req IPPV
Autonomic dysfunction
Tachycardiac / Arrhy
diaphoresis / retention
** Miller Fischer Syndrome / Variant
Invx
reg assess Vital capacity
CCM if <20mL/kg
CSF
Protein ↑
WCC normal
Nerve conduction study
distinguish axonal damage vs demyelination
MRI brain & S.Cord
Bloods
Antiganglioside autoantibody
antibody & serology
C jej / m. pneum / ebv / hsv / hiv / hep a-c / atypical
TFT B12 Folate paraprotein bands
Stool
C Jej / Polio / porphyria’s
Management
T/F to CCM
Resp compromise
Bulbar involvements
autonomic instability
a/B
A/B VC <15mL/kg - I+V Sux c/i - fatal hyperK Consider early trach - likely long wean
C
Caution w/ CVS instabilit during induction for I+V
autonomic dyfxn
CVS support require?
pacing for rx resistant brady
D
IV IG
400mg/kg OD x5/7
PLEX 400ml/Kg
3-5 Rx over 1/52
Early physio
flexion contractures / pressure sores / nerve palsies
Psych input
cognitive disturb
depression
** steroids no longer used - some books still talk about pulsed dose methylpred
Rx other
VTE proph
Early Enteral feeding
parenterally if ileus
Stress ulcer proph
Analgesia
Neuropathic analgesics
gabapentin
amitryp
Prognosis
Approximately 80 percent of patients are able to walk independently and more than half recover completely by one year. However, severe motor impairments persist in more than 10 percent