8 - Cytos Flashcards
mucocitus is associated with what cytos (3)
methotrex
flurouricil
anthracyclines (rubicins)
pre-disposing factors to tumour lysis syndrome (3)
features of tumour lysis syndrom (4)
hyperuricaemia, dehydration, renal impairment
features include :
high K, uric acis, phos and low Ca
two drugs for tumour lysis syndrome
allopurinol
rasburicase
when is the peak time for bone marrow supression
7-10 days after
what type of drugs might cause male sterility
alkylating agents
acute treatment for vomiting - low (2)
high (3)
dexamthasone and lorazepam
for higher risk - 5ht3 antag with dex
or
apreiptent
delayed onset n and v treatment (2)
5ht3 antag
metoclopramide
what type of cyto is associated with life threatening dose related cardio tox
anthracyclines (like -rubicins)
folinic acid is used for
recovery from methotrexate induced mucositis and myelosuppression
three drugs causing haemorragic cystitis
oxazaphosphorines
cyclophosphamide
ifosfamide
preventative therapy for haemorragic cystitis
mesna
name some alkylating drugs
risk of prolonged use of akylating agents (1)
carmustine
chroambucil
cyclophos
risk of secondary malgnancy
what type of drug is doxorubicin
what are some risks
anthracycline
cardiotox (liposomal formulations may reduced but increased infusion reactions like hand and foot)
elevated billirubin
what is dexrazoxane for?
anthracycline extraversation ofr prevention of toxicity (with things ending in rubicin)
what is palifermin?
for the meanagement of oral mucocytis
