7.4 Flashcards
It is important that blood glucose levels are kept relatively constant because glucose is the most important:
Respiratory substrate in humans
In a healthy human, blood glucose levels are normally kept at about
90mg per 100cm3 of blood
If blood glucose level changes significantly this will change the
Water potential of the blood - cells will gain or lose too much water through osmosis
The receptors that monitor blood glucose levels are found in the
islets of Langerhans in the pancreas
2 main kinds of cells in the islets of Langerhans:
α
β
α cells secret the hormone
Glucagon
β cells secrete
the hormone insulin
Blood glucose levels rise when a meal containing carbohydrates is eaten and glucose is absorbed into the
Blood
The rise in glucose is detected by the β cells in the islets of Langerhans.
Insulin travels in the blood and fits into specific receptors in the cell membranes of
Liver and muscle cells
Insulin release and blocking of receptors on cell membranes lowers blood glucose level in 4 ways:
- insulin stimulates the uptake of glucose by all respiring cells in the body (especially in liver and muscle cells). In these cells insulin causes glucose channels in plasma membranes to open, allowing more glucose to enter
- insulin stimulates an increase in respiration rate so more glucose is respites
- insulin activates enzymes inside liver and muscle cells, increasing the rate at which glucose is converted into glycogen. (GLYCOGENESIS)
- insulin activates other enzymes which convert glucose into fatty acids. These are converted into fats which are deposited in adipose tissue
Insulin is secreted until the blood glucose level returns to
Normal
Blood glucose levels can fall when a person has
-not eaten a meal for some time, especially if they have been very active
Fall in blood glucose level is detected by the
α cells - secrete hormone glucagon
(LBGL) glucagon, like insulin, binds to specific receptor proteins in plasma membranes. This activates enzymes that concert glycogen back to glucose. This process is called
Glucogenolysis
(LBGL) glucagon also stimulates the conversion of amino acids to glucose which results in more
Glucose being secreted into the blood