7.3: Skin disorders Flashcards

1
Q

What in the skin plays a role in cell signalling

A

Keratin

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2
Q

Keratinocytes in what skin layer lack nuclei or organelles

A

Stratum corneum

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3
Q

Where is melanin synthesised

A

In Melanocytes

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4
Q

Where does the vascular plexuses lie

A

In the dermis
Do not cross into epidermis

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5
Q

Characteristics of the reticular dermis

A

Superficial, composed of loose connective tissue

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6
Q

The skin has roles in what kind of immunity

A

Adaptive and innate

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7
Q

Where are T-cells resident

A

In the skin

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8
Q

Where are Langerhans cells resident

A

In the epidermis

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9
Q

What do keratinocytes synthesise

A

Antibiotics

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10
Q

3 functions of the skin

A

Thermoregulation
Immunity
Fluid balance

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11
Q

What nerve receptor senses vibration

A

Meissners corpuscle

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12
Q

What receptors sense pain and temp

A

Free nerve receptors

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13
Q

What receptors monitor skin stretch

A

Ruffini corpuscles

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14
Q

What receptors monitor light touch

A

Merkel cells

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15
Q

Function of desmosomes

A

Anchor keratins to the cell membrane

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16
Q

Function of adherens junctions

A

Bind intracytoplasmic actin

17
Q

Function of gap junctions

A

Contain intracellular channels that directly connect cytoplasm of adjacent keratinocytes
Essential for cell synchronization, cell differentiation, cell growth and metabolic coordination

18
Q

Function of connexons

A

Facilitate metabolic coordination between adjacent keratinocytes

19
Q

What occurs in the catagen phase of the hair cycle

A

Hair disconnected from blood supply and becomes club hair

20
Q

What happens in the Telogen phase of the hair cycle

A

Hair follicle is resting and hair shed.
Catagen cannot occur again until after anagen

21
Q

What skin condition does staphylococcus aureus contribute to

A

Eczema