7.1: The Intestines Flashcards
Describe the condition of chyme leaving the duodenum
*3 things
- Isotonic (water)
- Neutral (bicarbonate)
- Digestion nearly complete
How is absorption throughout the intestines accomplished structurally?
- A large surface area is achieved via villi, microvilli, plicae circularis and the general long length of the SI
- Slow movement for absorption to take place
Is absorption in the intestine primarily active or passive?
Mostly active
Describe how the intestinal mucosa is constantly renewed
Cells multiply in the crypts between the villi and migrate up towards the tips, maturing as they go. They then acquire the capacity to absorb and contribute to the micro-villi. They are eventually shed from the villus tips
Describe the composition and the job of the ‘unstirred layer’ of the intestine
Cells of the villi are active and secrete enzymes into the brush border, forming the ‘unstirred layer’. Here, almost digested nutrients are able to diffuse into the layer where the trapped enzymes complete digestion. Small molecules are released slowly out of the unstirred layer for absorption
Describe the two main components of starch
- Amylose; straight chains with a-1-4 bonds
2. Amylopectin; branched chains with a-1-6 bonds at branches
Describe the role of a-amylases. Where are they secreted from?
Salivary amylase breaks down the a-1-4 bonds in starch, and pancreatic amylase continues a-1-4 bond breakdown
They yield glucose and maltose from amyloses and a-limit dextrins from amylopectins
Name four brush border enzymes and how they continue carbohydrate digestion
- Isomaltase: breaks down branched molecules at a-1-6 bonds
- Maltase: breaks down maltose (a disaccharide) into two glucose molecules
- Sucrase: breaks down sucrose into glucose and fructose
- Lactase: breaks down lactose into glucose and galactose
How do glucose, galactose, fructose and lactose enter the mucosal cells?
Glucose: is absorbed actively into the mucosal cell via the Na+/glucose cotransporter SGLT1 (glucose is going against its concentration gradient). The Na/K ATPase on the basolateral side is important in maintaining a low Na+ concentration inside the cell for SGLT1. (There is also a K+ channel to balance the Na/K ATPase and allow the K+ back into the ECF)
SGLT1 also transports galactose
Fructose and lactose enter by facilitated diffusion (not linked to Na+)
How does glucose leave the mucosal cell and enter the ECF?
Facilitated diffusion on the basolateral side via the GLUT2 transporter
Describe how Oral rehydration works
By giving a mixture of glucose and sodium, this stimulates further uptake of sodium chloride, glucose and water into the body causing rehydration
Describe the enzymes involved in the digestion of proteins
*Including three main peptidases
- Stomach: pepsin from chief cells (likes the bond near aromatic acid side chains)
- Further peptidases released from the pancreas into the duodenum (as zymogens needing to be activated);
A) Trypsin (breaks down bonds near basic side chains)
B) chymotrypsin (breaks down bonds near aromatic side chains)
C) Carboxypeptidase (cleaves C terminal amino acids)
Which enzyme activates trypsinogen into trypsin and where?
Enterokinase in the brush border of the duodenum
How does the absorption of proteins change from a neonatal individual to an adult?
Adults can absorb amino acids and small peptides, whereas neonatals can absorb proteins such as IgG from breast milk to help develop their immune system
How are amino acids actively absorbed?
There are 5 active Na+/amino acid co transporters (mechanism exactly like the uptake of glucose) with different affinities for different amino acids