5.2: Liver and pancreatic disease Flashcards
In alcoholic liver disease, what is the basis of an enlarged abdomen, liver and spleen?
Destruction of normal liver architecture through cirrhosis reduces the liver’s production of albumin and the passage of blood flow through the liver - increasing pressure in the portal venous system. Since the portal system has no valves, this will raise the pressure in the splanchnic vasculature draining into it (causing spleenomegaly). A higher hydrostatic>oncotic pressure results in fluid leaking into the peritoneal cavity causing ascites.
What causes portosystemic anastomoses and what can happen as a result of this?
When the pressure/resistance in portal flow exceeds the pressure in the systemic veins, portal venous blood is diverted via the poro-systemic venous anastomoses which can become varicose as they enlarge
What term is used to describe the radiating dilated (varicose) veins seen on a patient’s abdomen
Caput medusa
Name three general types of liver function tests that can be done
- Hepatocellular damage; ALT/AST, y-GT (y-glutamic transpeptidase)
- Cholestasis (decrease in bile flow due to impaired secretion or obstruction); bilirubin (and alkaline phosphatase can suggest this)
- Test the liver’s function; albumin, prothrombin time, glucose
When is jaundice clinically detectable? Name the three ways jaundice is classified
> 40micromol/L
Classified three ways:
- Prehepatic (hemolytic - abundant unconjugated bilirubin in the blood)
- Hepatic (problem with the liver, cannot secrete and/or conjugate bilirubin)
- Post hepatic (cholestatic, obstruction to drainage so bilirubin can’t leave the liver)
What are three potential lab findings of prehepatic jaundice?
- Unconjugated hyperbilirubinaemia
- Reticulocytosis; immature RBCs (many new ones being formed to try to compensate for the excessive breakdown)
- Anemia
Name two inherited, one congenital and three acquired causes of pre-hepatic jaundice
Inherited: Hemoglobinopathies (i.e thalassemias, sickle cell, etc), metabolic defects
Congenital: Gilbert’s syndrome (benign, lack of function of the enzyme that conjugates bilirubin)
Acquired: drugs, burns, infections
What happens in hepatic jaundice and what are two potential complications?
Liver cannot manage the bilirubin its getting, leads to cell necrosis and can cause some cholestasis
Name four possible lab findings in hepatic jaundice
- Mixed unconjugated and conjugated hyperbilirubinemia: (unconjugated trying to get in, but if liver is partially working will have some conjugated)
- Raised AST/ALT: reflects liver damage
- Increased alkaline phosphatase: can reflect a degree of cholestasis
- Abnormal clotting
Name five causes of hepatocellular/hepatic jaundice
- Alcohol (can cause cirrhosis)
- Hepatic tumours
- Drugs (i.e paracetsamol)
- Wilson’s disease
- Hemochromatosis; hereditary where iron is despoted in the tissues leading to liver damage, diabetes and bronzer discolouration
What is characteristic of post-hepatic jaundice?
Obstruction of the biliary system so conjugated bilirubin cannot enter the duodenum
What are six potential lab findings of post-hepatic jaundice?
- Conjugated hyperbilirubinemia
- Dark urine; bilirubin in it
- Pale stools; bilirubin in it (steatorrhea)
- No urobilinogen in the urine (as it cannot enter the bowel and be converted/deconjugated)
- Increase in ALT/AST; liver damage
- Increase in canalicular enzymes (ALP); partly due to general cholestasis/everything is backed up
What are four intrahepatic and four extrahepatic causes of post-hepatic jaundice?
Intrahepatic (due to hepatic swelling)
- Hepatitis
- Drugs
- Cirrhosis
- Biliary cirrhosis (little bile ducts are blocked)
Extrahepatic (obstruction distal to the bile canaliculi)
- Gallstones
- Biliary stricture
- Carcinoma (esp. in the head of the pancreas)
- Pancreatitis
What is Courvoisier’s law?
In the presence of a non-tender palpable gallbladder, painless jaundice is unlikely to be caused by gallstones
Are you normally able to palpate gallstones?
No as they usually form over a long period of time as a result of a SHRUNKEN fibrotic gallbladder
Why does a gallbladder usually become enlarged?
Due to pathologies causing biliary obstruction over a shorter period of time (i.e like a malignancy)
What is hepatitis? When is it considered acute vs chronic and what lab signs would indicate for each?
Inflammation of the liver
Acute: if it’s less than 6 months (may see signs of jaundice and raised ALT/AST)
Chronic: >6 months
Liver failure, low albumin and low clotting factors
What are three main causes of hepatitis?
- Viral infection
- Toxins; alcohol, drugs (paracetamol), Wilson’s (copper), hemochromatosis (iron)
- Autoimmune
How might you acquire each of the three main types of viral hepatitis? Do they tend to cause acute or chronic inflammation and what are three potential complications of the third type?
Hep A: fecal-oral, mostly acute
Hep B: body fluids/blood and vertical spread, acute or chronic - may progress to cirrhosis
Hep C: blood spread
- 50% chronic liver disease
- 30% cirrhosis
- 5% hepatocellular carcinoma