7) Lymphoid Tissues Flashcards
What term is used to describe T cells that are mature but have not encounter antigens before?
naive
What Ab is expressed by immature B cells?
IgM
What Ab is expressed by mature B cells?
IgM and IgD
immature B cells are also known as what?
self-reactive B cells, meaning they will die if they encounter self antigens
Where will you find double positive T cells?
thymus only
What is also known as thymocyte graveyards?
Hassall’s corpuscles
Where will you find activated B cells in lymph nodes?
secondary follicles
Where will you find resting B cells in lymph nodes?
primary follicles
Where will you find proliferating B cells in lymph nodes?
germinal centers
T cells are found in this region of lymph nodes
paracortex
DCs are found in what areas?
T cell-rich areas
macrophages are found where in lymph nodes?
marginal sinus and medullary cords
How do lymphocytes get back to lymph nodes if it’s only one-way traffic through the lymphatic vessels?
HEVs
When lymphocytes circulate back into the lymph nodes, where do T and B cells go?
T cells remain in the paracortex while B cells must move past these T cells to get to the cortex. This movement of B cells increases the chance of T and B cell interactions
What organ produces the most Abs?
BM because that’s where majority of plasma cells reside
Lymphocytes prefer certain tissues due to adressins
lymphocyte homing
movement between organs provide better chances of encountering antigens
lymphocyte recirculation
Where do memory cells like to hang out? Which lymphoid tissues?
tertiary
APCs found in epidermis are called…
Langerhans cells
Lymph nodes, tonsils, Peyer’s patches, and the spleen are all …
secondary lymphoid tissues
Which lymphoid tissues are comprised mostly of skin and mucosa such as lungs, GI tract, and vagina?
tertiary lymphoid tissues
location where removal of RBCs occur in spleen
red pulp
location where removal of anitgens occur in spleen
PALS
Where are T cells found in spleen?
PALS
Which lymphoid tissue is the main responder for blood-borne antigens?
spleen
Which lymphoid tissue is the main responder for tissue-borne antigens?
lymph nodes
In MALT, antigens do not go through afferent lymphatic vessels, instead, they migrate via…
mucosal epithelium
What transports lymphocytes into Peyer’s patches?
HEVs
What cells transport proteins and microbes from intestinal lumen and into Peyer’s patches?
M cells
Where are Peyer’s patches found?
ileum of small intestine
Where do B and T cells reside in Peyer’s patches?
B cells are in follicles surrounded by a zone rich in T cells
What utilizes MALT?
GI tract, respiratory system and GU tract
