7) Lymphoid Tissues

Question 1

What term is used to describe T cells that are mature but have not encounter antigens before?

Answer 1

naive

Question 2

What Ab is expressed by immature B cells?

Answer 2

IgM

Question 3

What Ab is expressed by mature B cells?

Answer 3

IgM and IgD

Question 4

immature B cells are also known as what?

Answer 4

self-reactive B cells, meaning they will die if they encounter self antigens

Question 5

Where will you find double positive T cells?

Answer 5

thymus only

Question 6

What is also known as thymocyte graveyards?

Answer 6

Hassall’s corpuscles

Question 7

Where will you find activated B cells in lymph nodes?

Answer 7

secondary follicles

Question 8

Where will you find resting B cells in lymph nodes?

Answer 8

primary follicles

Question 9

Where will you find proliferating B cells in lymph nodes?

Answer 9

germinal centers

Question 10

T cells are found in this region of lymph nodes

Answer 10

paracortex

Question 11

DCs are found in what areas?

Answer 11

T cell-rich areas

Question 12

macrophages are found where in lymph nodes?

Answer 12

marginal sinus and medullary cords

Question 13

How do lymphocytes get back to lymph nodes if it’s only one-way traffic through the lymphatic vessels?

Answer 13

HEVs

Question 14

When lymphocytes circulate back into the lymph nodes, where do T and B cells go?

Answer 14

T cells remain in the paracortex while B cells must move past these T cells to get to the cortex. This movement of B cells increases the chance of T and B cell interactions

Question 15

What organ produces the most Abs?

Answer 15

BM because that’s where majority of plasma cells reside

Question 16

Lymphocytes prefer certain tissues due to adressins

Answer 16

lymphocyte homing

Question 17

movement between organs provide better chances of encountering antigens

Answer 17

lymphocyte recirculation

Question 18

Where do memory cells like to hang out? Which lymphoid tissues?

Answer 18

tertiary

Question 19

APCs found in epidermis are called…

Answer 19

Langerhans cells

Question 20

Lymph nodes, tonsils, Peyer’s patches, and the spleen are all …

Answer 20

secondary lymphoid tissues

Question 21

Which lymphoid tissues are comprised mostly of skin and mucosa such as lungs, GI tract, and vagina?

Answer 21

tertiary lymphoid tissues

Question 22

location where removal of RBCs occur in spleen

Answer 22

red pulp

Question 23

location where removal of anitgens occur in spleen

Answer 23

PALS

Question 24

Where are T cells found in spleen?

Answer 24

PALS

Question 25

Which lymphoid tissue is the main responder for blood-borne antigens?

Answer 25

spleen

Question 26

Which lymphoid tissue is the main responder for tissue-borne antigens?

Answer 26

lymph nodes

Question 27

In MALT, antigens do not go through afferent lymphatic vessels, instead, they migrate via…

Answer 27

mucosal epithelium

Question 28

What transports lymphocytes into Peyer’s patches?

Answer 28

HEVs

Question 29

What cells transport proteins and microbes from intestinal lumen and into Peyer’s patches?

Answer 29

M cells

Question 30

Where are Peyer’s patches found?

Answer 30

ileum of small intestine

Question 31

Where do B and T cells reside in Peyer’s patches?

Answer 31

B cells are in follicles surrounded by a zone rich in T cells

Question 32

What utilizes MALT?

Answer 32

GI tract, respiratory system and GU tract