7. Insulin signalling pathway

Question 1

What is PI3K?

Answer 1

Phosphoinositide 3 kinase

Question 2

Which enzyme catalyses the conversion of glucose-1-phophate to glycogen?

Answer 2

Glycogen synthase

Question 3

What is PKT?

Answer 3

Protein kinase C

Question 4

What is GSK3 and what does it do?

Answer 4

Glycogen synthase kinase 3. It phosphorylates glycogen synthase, inactivating it

Question 5

What do kinase and phosphatase enzymes do?

Answer 5

Kinase - phosphorylates

Phosphatase - dephosphorylates

Question 6

What is ATP - citrate lyase (ATP CL) responsible for?

Answer 6

Fatty acid synthesis

Question 7

What is IRS1?

Answer 7

Insulin receptor substrate 1

Question 8

What is PIP?

Answer 8

Phosphatidylisinotol

Question 9

What is AKT?

Answer 9

Protein kinase B

Question 10

What is PDPK1?

Answer 10

3-phosphoinositide dependent kinase 1

Question 11

What does the phosphatase and tensin homolog (PTEN) gene do?

Answer 11

Created phosphatase, which dephosphorylates PIP3 to PIP2

Question 12

To respond to insulin, receptor subunits come together as a…

Answer 12

..dimer