7: GF Signalling II Flashcards by joe tr | Brainscape

Q

How many patients with HER2+ metastasic BC will initially respond to trastuzumab?

A

<50%

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Q

What are the 3 mechanisms of resistance to trastuzumab

A

Enzymatic cleavage of HER2 (p95HER2 lacks trastuzumab binding site)
Epitope masking (interferes with trastuzumab binding & activity)
Constitutive activation of downstream (PI3K) signalling pathways

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