7- Erythema And Urticaria Flashcards
Erythema multiforme minor is usually caused by
HSV infection
Erythema multiforme major is most often caused by
Mycoplasma infection
Recurrent self limited disease
Sharply marginated, erythematous macules then evolve to papules
Target lesions observed in palms and soles
Koebner phenomenon
EM minor
Type of EM: Frequently accompanied by a febrile prodrome
Lesions on extremities and face, may include trunk
Mucous membrane disease prominent
EM major
Sharply marginated rapidly extending, tender, erythematous or violaceous, painful, elevated plaque, 2-10cm diameter
Face, neck, upper trunk and extremities
May burn but do not itch
Fever
Sweet syndrome
Acute febrile neutrophilic dermatosis
Majority of cases of Sweet syndrome follow this infection
URTI
Pregnancy associated Sweet syndrome usually presents in what trimester
1st or 2nd
Treatment for Sweet syndrome
Self limited
Oral prednisone 1mg/kg/day
Begins as an inflammatory pustule with a surrounding halo that enlarges and begins to ulcerate
Lower extremities and trunk
Pyoderma gangrenosum
Least aggressive form of pyoderma gangrenosum
Vegetative
Disease most often associated with pyoderma gangrenosum
IBD
Most common inherited auto inflammatory syndrome
Familial Mediterranean fever
Autosomal recessive
Recurrent 12-72h of fever and monoarthritis and erysipela like erythema
Familial Mediterranean fever
Treatment for familial Mediterranean fever
Colchicine
Vascular reaction of the skin characterized by appearance of wheals surrounded by red halo or flare with severe itching
Caused by localized edema
Urticaria
Acute and chronic urticaria timeline
Acute <6 weeks
Chronic >6 weeks
Sharply localized edema or wheal with a surrounding erythematous flare after the skin has been stroked
2-5% of population
Dermatographism
Cholinergic urticaria is produced by the action of acetylcholine on what cell
Mast cell
Adrenergic urticaria is mediated by this hormone
Norepinephrine
Management of cholinergic and adrenergic urticaria
Adrenergic- propranolol
Cholinergic- antihistamines
Angioedema in the absence of urticaria can be due to
Hereditary angioedema
ACE inhibitor
