7 - Cholinoceptor antagonists

Question 1

Which of the following drugs has efficacy for the muscarinic acetylcholine receptor?
A.	Acetylcholine
B.	Atropine – antagonist 
C.	Acetyl-cholinesterase
D.	Adrenaline
E.	Acetate

Answer 1

A. Acetylcholine

Question 2

Which of the following effects would be observed at rest after treatment with a ganglion blocking drug?
A.	Increased heart rate
B.	Pupil constriction
C.	Bronchodilation
D.	Detrusor contraction
E.	Increased gut motility

Answer 2

A. Increased heart rate

C. Bronchodilation

Question 3

Which of the following drugs would you administer to treat an atropine overdose?
A.	Bethanechol
B.	Ecothiopate 
C.	Hyoscine 
D.	Physostigmine 
E.	Pralidoxime

Answer 3

D. Physostigmine – anticholinesterase - reversible

A. Bethanechol – Musc R angonist - set up competitive reaction with atropine
B. Ecothiopate – irreversible anticholinesterase – not preferred
C. Hyoscine – musc R antagonist atropine-like, dont use.
E. Pralidoxime – recovers cholinesterase function