2 - Drug receptor interactions

Question 1

Which of the following statements is most accurate?

A: A partial agonist will always have a higher efficacy than a full agonist
B: Agonists have higher affinities than antagonists
C: Full agonists that are selective for a given receptor will have the same efficacy
D: Antagonists possess better efficacy than their respective agonists
E: Competitive antagonists will preferentially occupy the relevant receptor in the presence of agonist

Answer 1

C: Full agonists that are selective for a given receptor will have the same efficacy

Question 2

A drug acting as an inhibitor at a particular drug target site prevents the removal of neurotransmitter from the synapse. Which type of drug target is this drug acting on?

A: Receptor
B: Voltage-sensitive ion channel
C: Receptor-linked ion channel
D: Transport protein
E: Non-proteinaceous target

Answer 2

D: Transport protein