7 - Cell Cycle, mitosis and meiosis Flashcards
Telomeres
G rich ends of chromosomes
Cohesins
proteins that join sister chromatids
Kinetochores
Microtubule binding structure, one per chromatid, on either side of centromere. Microtubules attach to both kinetochores and pull sister chromatids apart
What ware spindle microtubules composed of
Tubulin subunits
Centrosome
Contains two centrioles at right angles. Where microtubules assemble
Nondisjunction
Incorrect segregation of chromosomes
homologous chromosomes
Two chromosomes in a pair
chromatin
decondensed chromosome
Phases of cell cycle
G1, S, G2, M
Phases of M phase
Prophase, Prometaphase, Metaphase, Anaphase, Telophase
Prometaphase
Nuclear membrane disintegrates. Spindle microtubules attach to kinetochores
Prophase
Chromosomes condense. mitotic spindle forms
Metaphase
Chromosomes line up on metaphase plate
Anaphase
Sister chromatids seperate and move towards pols
Results of mitosis
2 cells with same number of chromosomes as parent cells (both 2n)
results of meiosis
4 cells with half the number of chromosomes as parent cells (each n)
Crossing over
Unique to meiosis, exchange of genetic material between members of each homologous pair of chromosomes. Allows genetic variation
Chiasma
Site of crossing over
seperation of tetrads during anaphase 1
Cohesin along chromosome arms break down allowing homologs to seperate but cohesin at centromere is protected by shugoshin. Shugosin degraded allowing chromatids to seperate.
Metaphase in mitosis
Individual chromosomes line up
Metaphase in meiosis 1
Homologous pairs line up
Metaphase in meiosis 2
Individual chromosomes line up
When does crossing over occur
prophase 1
Random & independent alignment of
chromosomes
Metaphase 1
Random & independent distribution of chromosomes
Anaphase 1
Anaphase in mitosis
Chromatids seperate
Anaphase in meiosis 1
Homologous chromosomes seperate
anaphase in meiosis 2
Chromatids seperate