7. Agents against hepatitis viruses

Question 1

hepatitis viruses

Answer 1

HCV & HBV

Question 2

Agents against hepatitis viruses

Answer 2

Interferon α2a & α2b

Question 3

Interferon α2

Answer 3

for HBV and HCV (also for KS, Malignant melanoma, hairy cell leukemia)

Administration: administered subcutaneously, IV
”pegylated” derivatives are preferred, because of better kinetic properties (once a week is possible)
Kinetics: liver metabolism
excretion by the kidney

Adverse effects:
Flu like symptoms (fever, fatigue, myalgia, etc.) GI problems ,CNS problems
Suppression of the haematopoiesis

Question 4

Agents against hepatitis C virus

Answer 4

Ribavirin

Question 5

Ribavirin

Answer 5

synthetic guanosine analog
Effective against a wide range of RNA and DNA viruses (HSV, VZ, influenza A, B, RSV, HCV

Administration: oral, aerosol (used to be used, RSV)
HSV: combined for 12-48 weeks orally
RSV infection in children: 3-7 days inhaled

Adverse effects: Dose dependant hemolytic anemia and bone marrow suppression | Teratogenic

Question 6

Agents against hepatitis B virus

Answer 6

Nucleotide / nucleoside analogs of HBV

Question 7

Nucleotide / nucleoside analogs of HBV

Answer 7

cuses DNA chain elongation termination

drugs ...
Lamivudin 
Adefovir 
Entecavir 
Telbivudine

Question 8

Telbivudine

Answer 8

Thymidine analog

Oral administration
Excretion: Kidney

Question 9

Lamivudin

Answer 9

Cytosine analog

Question 10

Adefovir

Answer 10

AMP analog

Excretion: Kidney

Adverse effects: Nephrotoxicity in chronic use Exacerbation in discontinuation

Question 11

Entecavir

Answer 11

Guanosine analog

For lamivudine resistant strains of HBV