67. Factors and hormones. Toxic shock syndrome during menstruation. Flashcards
hormones effects depend on ?
the circulating concentration
concentration or receptors
the sensitivity of the receptors
what are all all the hormones the ovaries secret ?
oestrogen
progesterone
testosterone
inhibin
actions of estrogen on vagina ?
epithelilal proliferation
increased in glycogen stores - and feeds the lactic acid producing bacteria naturally occurring in the vagina
actions of estrogen on the cervix
increase mucus production
dilation of cervica; canal
action of estrogen on uterus
proliferation of the endometrium the functional layer
causes the coiled arteries for angiogensisi
increases myometrial contractility
action of estrogen in the fallopian tubes
increases secretion
higher motility
effect of estrogen on the lungs ?
increased vital capacity
effect of oestrogen on the bone ?
stimulates osteoblasts - bone formation
effect of estrogen on skin and connective tissue ?
collagen and mucopolysaccharides
effect of estrogen on vascular system ?
vasodilation
activation of RAAS
increased vessel perm
- antihypertensive
effect of oestrogen in coagulation
increased coagulation promoting and coagulation inhibiting activity
what is the effect of estrogen on fat metabolism
decreased LDL
increased HDL / VLDL
action of progesterone on vagina ?
disqualification of epithelial cells
action of progesterone on the cervix ?
mucus plug
cervical canal contract
what is the action of progesterone on the uterus ?
reduce ontrcatiity
secretary conversion of endometrium
what is the action of progesterone on the fallopian tube ?
decreased secretion and contraction
what is the action of progesterone on mammary glands ?
development of lactating system
what is the action of oestrogen on CNS ?
increased libido and mood lifting
action progesteron on CNS ?
sedative
action of progesterone on fat metabolism ?
increased LDL
decreased HDL
action of androgens ?
libido
increases pubic hair growth
anabolic
mitogenic
what inhibits FSH and LH?
dopamine , acetylcholine and opioids
what drug causes excretory effect of FSH and LH
noradrenaline
where is prolactin produced ?
anterior pituitary
where is oxytocin produced ?
nucleus paraventriculus of the hypothalamus
bacterial etiology Toxic shock syndrome during menstruatiom
strep progenies
staph aureus
what introduced strep pyogenes and stop areas ?
very absorbent tampons
strep pyo - individual with preexisting skin infections
signs and symptoms of TSS on staph aureus ?
high fever,
low blood pressure,
confusion-can rapidly progress to stupor, coma
multiple organ failure
characteristic rash, resembling a sunburn
in patients who survive the initial phase the rash desquamatises and peels off after 10-21 days
non purulent conjunctivitis
profuse watery diarrhoea
signs and symptoms of TSS on strep ?
same but pain on sight of infection
less sunburn like lesions
pathophysiology of TSS
superantigens interact directly with the MHC-II molecules , instead through antigen representing cells
resulting in activation of t cells in mass
causing cytokine storm
leasing the multisysem organ failure
what is the treatment of TSS ?
administration to the ICU
fluid managment, ventilation, renal replacement therapy
administer antibiotics
combo of cephalosporins m penicillin and vancomycin if needed
