6.13 Fatty Acid Synthesis & Eicosanoids

Question 1

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Answer 1

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Question 2

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Answer 2

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Question 3

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Answer 3

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Question 4

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Answer 4

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Question 5

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Answer 5

a

Question 6

fatty acid synthesis

Answer 6

When carbs are converted to palmitic acid. Steps: Carbs -> glycolysis -> glucose -> pyruvate -> citrate -> citrate lyase -> acetyl CoA -> Acetyl CoA carboxylase -> Malonyl CoA -> Fatty acid synthase/NADPH -> palmitate

Question 7

What are the two sources of NADPH for fatty aid synthase?

Answer 7

Malic acid enzyme (recycling of OAA) and the pentose pathway

Question 8

Two enzymes required for Fatty Acid Synthesis? Which one is the rate controlling step?

Answer 8

Acetyl CoA Carboxylase (ACC), Fatty Acid Synthase

Question 9

What regulates ACC? State which ones stimulate and which ones inhibit: Citrate, Insulin, Caloric intake, Glucagon/Epinephrine, Pamitoyl CoA levels, AMP (low energy levels)

Answer 9

Stimulated by Citrate, Insulin, Caloric intake. Inhibited by Glucagon/Epinephrine, Pamitoyl CoA levels, AMP (low energy levels)

Question 10

Steps in Fatty Acid synthesis

Answer 10

1. Activation: carboxylation of acetyl CoA to malonyl CoA, 2. Condensation: formation of the B-keto group, 3. Reduction of the B-keto group, 4. Dehydration of the a,b carbons, 5. Reduction of the a,b double bond