(6.1) Pulmonary Hypertension (Wolff) Flashcards
What are the (4) prostanoids?
-prost
Epoprostenol
Treprostinil
Iloprost
Selexipag
What are the (2) PDE 5 inhibitors?
-afil
Sildenafil
Tadalafil
What are the (3) endothelin antagonists?
-sentan
Bosentan
Ambrisentan
Macicentan
What is the (1) guanylate cyclase sensitizer?
Riociguat
If you get a positive CCB vasopressor test…
What drugs do you use?
Nifedipine
Diltiazem
Amlodipine
What is the primary target for the drugs we are learning for this lecture?
Pulmonary aterial hypertension (PAH)
What is the definition of PAH?
Sustained elevation of mean pulmonary arterial pressure (mPAP) is
greater than or equal to 25mmHg at rest
What is the normal pulmonary pressure?
14 plus or minus 3 mmHg
What population is typically affected by pulmonary HTN?
Young women
What is pulmonary arterial hypertension (PAH) characterized by?
Progressive increase in pulmonary vascular resistance (PVR)
What does PAH eventually lead to (anatomically)?
Right ventricular overload –> right ventricular failure = premature death
What are the EARLY symptoms of PAH?
Dyspnea upon exertion
Fatigue
Chest pain
Tachycardia
Pain on the upper right side of the abdomen
Anorexia
What are the LATE symptoms of PAH?
Syncope
Swelling in legs and ankles
Cyanotic lips and skin
What is a MAJOR genetic correlation to produce PAH?
BMPR2
What is a MAJOR drug that can predispose pts to PAH?
Fenfluramine/phentermine
“fen/phen” weight loss pill