6 - Troches Flashcards
Types of Ointment Bases used in TROCHES
Oleaginous Bases
Cocoa
Water-Soluble Bases
PEG
Aqueous (hydrophilic) Bases
Gycerinated Gelatin / Sugar based
Types of Semi-Solid Troches
Hard = Lozenges
anesthetic throat lozenges
Soft = Pastilles
PEG / Chocolate soft troches
Chewable / Gummies / Soft Chocolates
vitamin gummies
also there are Compressed Tablets
Unique AAdvantage of HARD TROCHES
if using local anethetic
DIRECT PAIN RELIEF
to the oral mucosa
Unique advantage of SOFT TROCHES
enable BUCCAL ABSORPTION of drugs
at a lower dose vs conventianal swallow tablets
Hard Troche FORMULATIONS
Lozenges / Lollipops / Drops
SUGAR-Based (Lollibase)
Drug has to be able to withstand HIGH TEMP
“Candy thermometer” to test Temp want between
_310-316*F = 154-160*C_
(anything above 316/160 will caramalize)
in order to REMOVE WATER –> then pour into molds
Soft Troche (Pastilles) FORMULATION
Semi-solid or SOFT dosage forms
SUGAR + WAX + PEG
(PEG= Water soluble base)
drug stability is STILL an issue due to HIGH TEMP
MELT -> Add Drug -> Mix -> POUR INTO MOLDS
Chewable Troche = Gummy
FORMULATION
GELATIN (Glycerinated gelatin = Aqueous base)
or other polymeric (cellulosic) Materials
Drug + Gelatin + Glycerin + JELLO + Water + other binders
Pharmacologic Advantages of TROCHES
Avoid stomach pH / enzymatic degradation
Avoid First-Pass metabolism
Irritating Drugs
TASTE
Therapeutic APPLICATIONS for Troches
Advantages
Steroid Therapy
Analgesic
Anti-Smoking
Vitamins
Local/Topical Effects
of TROCHES
Local Antibiotic effects
Local Anesthetic/Analgesic effects - Hard Troches (lollipops)
Sore throats / oral Lesions
Emollient
Demlcent
Systemic Absorption
of Troches
may be CHEWED or SWALLOWED
Buccal Absorption
drug is absorbed through the buccal mucosa,
avoids First-pass metabolism & stomach pH / enzyme degradation
Gastric Absorption
Benzocaine Lozenge
HARD TROCHE
with Menthol + Benzocaine
Corn Syrup + Propylene Glycol + SUCROSE / CORN STARCH
Ideal Temperature for removing water for
HARD TROCHE
310-316*F
154-160*C
leaves a AMORPHOUS SUGAR MASS w/ Drug
for TRANSFER TO MOLD
Soft Crack Stage
Stage in hard troche compounding process, where you heat the sugar
_132-143*C_
sugar concentration is 95%
will bend when a drop is placed in COLD water
>160*C will CARMELIZE / BURN
HARD Crack Stage
Stage in hard troche compounding process, where you heat the sugar
_148-154*C_
sugar concentration is 99%
will CRACK when a drop is placed in COLD water
_>160*C will CARMELIZE / BURN_
