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Ceutics2 - Midterm 1 > 5 - Suppository Products > Flashcards

5 - Suppository Products Flashcards

1
Q

Comminution

vs

Trituration

A

Particle Size Reduction ONLY

Grinding & Mixing in mortar & pestle to reduce particle size

Electric grinder + Sieve

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2
Q

Type of Solvent that has

HIGH Dielectric Constant

HIGH Polarity

A

POLAR

Water

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3
Q

Type of Solvent that has

Medium Dielectric Constant

Medium Polarity

A

Semi-Polar

Alcohol or Glycol

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4
Q

Type of Solvent that has

Low Dielectric Constant

Low Polarity

A

Non-Polar SOlvent

Mineral oil / Benzene

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5
Q

Types of Ointment bases used in

Suppositories

A

Oleaginous Base

Absorption (W/O Base)

Water Soluble (PEG)

Aqueous (hydrophilic Gel, methylcellulose)

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6
Q

How to make a STICK?

A

Ointment Base + WAX

More WAX –> INCREASED MELTING POINT

(harder)

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7
Q

2 Types of Gels

dispersions in AQ vehicle rendered jellylike by addition of a gelling agent

consist of carbomers + cellulosics

A

Single Phase

Two-Phase = Magma

ex. Milk of Magnesia

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8
Q

Local Actions of Suppositories

A

Topical Effects

Emollient / Laxative

Anesthetic

Steroid

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9
Q

Systemic Action of Suppositories

A

Analgesic / Antipyretic

Epileptic

Anti-emetic/nausea

Asthma

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10
Q

Advantages of Suppositories

A

AVOID:

Stomach pH / enzyme degradation / FIRST PASS metabolism

good for irritating drugs / vomiting patients

Children / uncooperative patients

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11
Q

Physiologic Factors that affect Absorption

for suppositories

A

Colonic Content

Circulation

hemorrhoidal veins / lymphatic circulation

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12
Q

PHYSICOchemical Factors that affect absorption

​for suppositories

A

neutral pH

no buffer capacity

partition coefficient

particle SIZE

composition of suppository base

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13
Q

3 main Requirements for suppository BASES

A

Melt / Dissolve @ body temp ~37*C

Inert

Relationship to ointment bases

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14
Q

Types of Suppository Bases

A

Oleaginous (fatty) = Cocoa Butter

MELT @ body temp

Water-Soluble / miscible = Glycerinated Gelatin

slowly dissolve –> slower release

W/O Emulsions / polyoxyl 40 stearate / witepson

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15
Q

Suppositories have the MOST RAPID RELEASE

when the drug is in base

Solubility + Hydrogen bonds are what affect Drug release of suppositories

A

INSOLUBLE

Phenobarb in PEG base (hydrophilic)

Sodium Phenobarb in hydroPHOBIC base

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16
Q

What is best in terms of Polarity & Solubility

of the Drug vs the Base?

A

Drug INSOLUBLE in base = RAPID RELEASE

Drug has OPPOSITE POLARITY vs the base = Rapid release

Solubility + Hydrogen bonds are what affect

Drug release of suppositories

17
Q

Ways to Prepare Suppositories in Compounding

A

Molding

Melt + Mix + Pour –> cast iron molds / disposable molds

Compression

COLD compression on mass

Hand-Rolling + Shaping

18
Q

OTC Suppository products generally have a

effect

A

LOCAL EFFECT

Ex. Hydrocortisone / Biscodyl

Mesalamine / Preparation H

Vasoconstrictor / Anesthetic / Protectants

19
Q

What type of lubricant do you use for a suppository with a

(hydrophobic base) Oleaginous Base?

Suppository Compounding

A

GLYCERIN lubricant

(hydroPhilic)

Use lubricant of OPPOSITE polarity vs suppository base

20
Q

What type of lubricant do you use for a suppository with a

PEG / Glycerinated Gelatin ​(HydroPhilic Bases)?

Suppository Compounding

A

MINERAL OIL lubricant

hydroPHOBIC

Use lubricant of OPPOSITE polarity vs the suppository base

21
Q

What type of preperation do you use for a

low-dose drug?

Suppository Compounding

A

WEIGHT CALCULATION

based on density

22
Q

What type of preperation do you use for a

HIGH DOSE drug?

Suppository Compounding

A

DOUBLE POUR preperation

  • Pour #1 -
    • Drug + 1/2 base, QS with remaining base
      • COOL -> SCRAPE -> REMOVE
  • ​​Pour #2 -
    • ​RE-MELT
      • pour -> remove –> Dispense
23
Q

Vaginal Inserts/Tablets/Capsules

(Pessaries)

primarally LOCAL application

A

OBLONG SHAPE

typically use PEG (water-soluble) BASE

Applicator for insertion

Antibiotics / Antifungals / Spermatocides

Hormones / Contraceptive

WET VAGINAL TABLETS FIRST

24
Q

Stability Considerations for Suppositories

A

Chemical / Physical

COOL STORAGE & AVOID HUMIDITY

Cocoa butter -> fridge / Glycerinated Gelatin –> cool place

PEG –> room temp

MICROBiological

Therapeutic / Toxicological

25
Q

OTC Rectal Suppositories

A

LOCAL EFFECT =

Vasoconstrict / Anesthetic / Protectants

Anusol

Tucks

Preparation H

26
Q

Prescription Rectal Suppositories

w/ LOCAL EFFECT

A

Bisacodyl

Hydrocortisone

Mesalamine

27
Q

Prescription Rectal Suppositories

​w/ Systemic Effect

A

Chlorpromazine / Prochlorperazine

HydroMORPHONE / OxyMorphone

Indomethacin

Promethazine

28
Q

Type of OLEAGINOUS Base used in Suppositories

A

FATTY BLEND

Cocoa Butter

29
Q

Type of Absorption Bases (hydroPhilic) used in Suppositories

A

Witepsol

30
Q

Type of Water-Soluble Base / Water-Miscible Base use in suppositories?

(HydroPHOBIC)

A

PEG / Glycerinated Gelatin

Water-Miscible = Aqueous Base = Hydrophilic Base use GELATIN

Ceutics2 - Midterm 1 (7 decks)

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