6 - Therapy & Alternative RCT designs Flashcards
what is n of 1 RCT?
an RCT in just 1 patient
- ie randomized to different treatments over time
- includes washout period, etc
why do we use n of 1?
- p 70
describe design of n of 1
- p 70
when should you conduct n of 1? when appropriate to stop?
- p 70/71
what is a run-in/when do you do it?
- p 70
what is the inverse rule of 3s?
- p 71
what is a crossover RCT?
- each subject is his own control, which removes some of the noise! (like n of 1 but now involves a group)
- same as CT, but this time everyone has done every condition!
describe the crossover design/conditions for it
- p 72
describe carry-over effects
- p 72
describe order effects
- p 72
what are cluster randomized trials? used for what?
p 73
what is intra-cluster correlation? how do we account for this? n-size relation?
p 73
what is a factorial design trial?
p 74 and example on p 75/76
when is factorial design efficient?
p 76
what is expertise-based trial/what type of trial design is it? explain problems with expertise-based trials.
- randomized trial design, p 77/78
describe an interaction for factorial designs/ n-size effect
p 76
what is differential expertise-bias?
p 77
when is individual clinician equipoise important?
p 78
advantages/disadvantages for expertise-based design?
p 79
explain contamination wrt expertise-based design
p 78
explain pragmatic vs explanatory approach for expertise-based design
p 79
