6 - Therapy & Alternative RCT designs Flashcards
1
Q
what is n of 1 RCT?
A
an RCT in just 1 patient
- ie randomized to different treatments over time
- includes washout period, etc
2
Q
why do we use n of 1?
A
- p 70
3
Q
describe design of n of 1
A
- p 70
4
Q
when should you conduct n of 1? when appropriate to stop?
A
- p 70/71
5
Q
what is a run-in/when do you do it?
A
- p 70
6
Q
what is the inverse rule of 3s?
A
- p 71
7
Q
what is a crossover RCT?
A
- each subject is his own control, which removes some of the noise! (like n of 1 but now involves a group)
- same as CT, but this time everyone has done every condition!
8
Q
describe the crossover design/conditions for it
A
- p 72
9
Q
describe carry-over effects
A
- p 72
10
Q
describe order effects
A
- p 72
11
Q
what are cluster randomized trials? used for what?
A
p 73
12
Q
what is intra-cluster correlation? how do we account for this? n-size relation?
A
p 73
13
Q
what is a factorial design trial?
A
p 74 and example on p 75/76
14
Q
when is factorial design efficient?
A
p 76
15
Q
what is expertise-based trial/what type of trial design is it? explain problems with expertise-based trials.
A
- randomized trial design, p 77/78
