6: Preterm infants Flashcards

1
Q

Before which point in gestation is a birth pre-term?

A

37 weeks

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2
Q

Birth before ___ weeks is incompatible with life.

A

22 weeks

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3
Q

Fatal birth before 22 weeks is also known as what?

A

Foetal loss

or Miscarriage

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4
Q

At which point in gestation is a birth at term?

A

38 - 42 weeks

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5
Q

Pre-term babies are more likely to have a (high / low) birth weight.

A

low birth weight

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6
Q

Which lifestyle choice has an effect on the rates of pre-term delivery?

A

Smoking

Smoking ban saw a 10% decrease in pre-term births

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7
Q

What is a neonatal death?

A

Death within the first four weeks of life

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8
Q

Which type of pregnancy is associated with pre-term birth?

A

Multiple pregnancy

Ferguson reflex - increased distension of uterine walls

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9
Q

The majority of pre-term births are ___ in origin.

A

idiopathic

nobody knows why

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10
Q

Having more than one baby in the womb is a common cause of ___ delivery.

A

pre-term

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11
Q

A history of ___ delivery increases a woman’s risk of pre-term delivery.

A

pre-term delivery

cumulative effect

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12
Q

Pre-term babies are more vulnerable to ___ stress, have less developed ___ and are more likely to be (hyper/hypo)glycaemic.

A

vulnerable to cold stress - less brown fat

less developed lung - less surfactant

hypoglycaemic - less glycogen reserves

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13
Q

What is the purpose of delayed cord clamping?

A

Allows maximum volume of blood to transfer from mother to baby

–> reduce chances of anaemia, hypovolaemia

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14
Q

What does cold stress lead to in premature babies?

A

Hypothermia

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15
Q

How does hypothermia cause hypoglycaemia in babies?

A

Increased non-shivering thermogenesis

Which uses glycogen stores

When glycogen is depleted, free circulating glucose is used up

> Hypoglycaemia

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16
Q

How does hypothermia cause hypoxia in premature babies?

A

Increased oxygen demand due to increased thermogenesis

> Hypoxia and metabolic acidosis (anaerobic respiration)

17
Q

How are pre-term babies initially fed?

A

Parenteral nutrition

18
Q

What is the risk of parenteral feeding in pre-term babies?

A

Infection

As it involves IV access

19
Q

Which disease, involving widespread ischaemia of the bowel, can be treated using parenteral nutrition?

A

Necrotising enterocolitis (NEC)

20
Q

What is the ideal form of feeding for babies?

A

Exclusive breastfeeding

21
Q

If a mother can’t breastfeed, what forms of nutrition can be offered to pre-term babies?

A

Donor milk

Formula milk

22
Q

What can untreated infection cause in neonates?

A

Neonatal sepsis

23
Q

What are the two forms of neonatal sepsis seen in babies?

A

Early onset - probably acquired during pregnancy / birth

Late onset - acquired post-birth

24
Q

What are the most common bacteria causing

a) early-onset
b) late-onset neonatal sepsis?

A

a) Group B Strep, Coliforms

b) Coagulase negative Staph i.e Staph epidermidis

25
Q

What causes respiratory distress in pre-mature babies?

A

Lack of pulmonary surfactant

26
Q

Which abnormal breathing patterns can pre-mature babies present with?

A

Transient tachpynoea

Apnoea

27
Q

How does a baby with respiratory distress present?

A

Cyanosis

Tachypnoea

Intercostal/sternal recession

Nasal flaring

Grunting

28
Q

How is a baby with respiratory distress managed?

A

Steroids

Ventilation

CPAP

29
Q

What appearance do the lungs have on CXR in a baby with respiratory distress?

A

Ground glass appearance

30
Q

None of the blood in the foetal circulation has a large oxygen concentration.

What helps a baby to get around this?

A

Foetal Hb

31
Q

Which type of brain bleed are pre-term babies at risk of?

How is a baby’s risk reduced?

A

Intraventricular haemorrhage

Magnesium sulphate

32
Q

Which GI condition is seen almost exclusively in pre-term babies and carries a high mortality rate?

A

Necrotising enterocolitis (NEC)

33
Q

What are the signs of NEC on an abdominal X-ray?

A

Dilated bowel loops

Pneumoperitoneum

34
Q

The greater a baby’s gestational age (up to term), the (better / worse) their chances of survival.

A

greater gestational age > greater likelihood of survival

so every week in the womb counts