6 - Nervous System Organisation Flashcards

1
Q

Describe the levels of biological organisation

A

Atoms -> molecules -> organelle -> cell -> tissue -> organ -> organ system
-> organism

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2
Q

Describe response to picking up a glass of water

A

Stimulus (glass) -> sensory receptor (eye) -> sensory neuron -> relay neuron (in brain) -> motor neuron -> effector (bicep muscle) -> response (pick up glass)

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3
Q

What are the 2 subdivisions of the nervous system?

A

CNS and PNS

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4
Q

What is the CNS composed of?

A

Brain and spinal cord

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5
Q

What’s the PNS composed of?

A

Everything else

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6
Q

What’s a nerve?

A

Bundle of axons from multiple neurons

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7
Q

What do the parasympathetic and sympathetic divisions control?

A

Homeostasis and functions beyond voluntary control

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8
Q

Parasympathetic

A

Rest & digest

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9
Q

Sympathetic

A

Fight or flight

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10
Q

Rostral

A

Front/towards nose

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11
Q

Caudal

A

Back/towards tail

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12
Q

Dorsal

A

Top/towards back

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13
Q

Ventral

A

Bottom/towards belly

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14
Q

Lateral

A

Left/right

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15
Q

Medial

A

Middle

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16
Q

Coronal

A

Frontal

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17
Q

Sagittarius

A

Plane straight down nose

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18
Q

What are the key areas of CNS?

A
  1. Spinal cord connects brain w/ PNS
  2. Brain stem
  3. Cerebellum
  4. Diencephalon
  5. Cerebrum
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19
Q
  1. Spinal cord connects brain w/ PNS
A

Conduit for info — sends out motor info and receives sensory info

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20
Q

What’s the central gray matter of the spinal cord?

A

Cell bodies

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21
Q

What’s the peripheral white matter of spinal cord?

A

Myelinated axons

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22
Q

Where are the cell bodies of sensory neurons in spinal cord?

A

Dorsal root ganglion

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23
Q

Where do sensory neuron axons enter spinal cord?

A

Dorsal root

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24
Q

Where do sensory neurons synapse in spinal cord?

A

Dorsal horn

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25
Q

Where are motor neuron cell bodies in spinal cord?

A

Ventral horn

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26
Q

Where do motor neuron axons exit in spinal cord?

A

Ventral root

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27
Q

Where do motor neurons synapse?

A

on muscle fibres

28
Q

What’s the brain stem composed of?

A

Medulla, pons and midbrain

29
Q
  1. Cerebellum
A

Role in motor control — motor learning, coordination and incorporating sensory feedback

30
Q

What cognitive functions is the cerebellum implicated in?

A

Attention and language

31
Q
  1. Diencephalon
A

Contains thalamus, hypothalamus, pituitary gland, pineal gland and corpus callosum

32
Q

Thalamus

A

Relay station and gateway controlling flow of sensory & motor signals to/from cerebrum. Regulates sleep, consciousness and alertness

33
Q

Hypothalamus

A

Regulates metabolic processes

34
Q

Pituitary gland

A

Endocrine gland critical for homeostasis

35
Q

Pineal gland

A

Endocrine organ modulates sleep

36
Q

Corpus callosum

A

Cut in extreme seizures — unable to transfer info between 2 sides of brain

37
Q
  1. Cerebrum
A

Cerebral cortex, basal ganglia and limbic system

38
Q

Cerebral cortex

A

Outermost sheet of neural tissue. Sensory perception, motor control, affect, cognition

39
Q

Basal ganglia

A

4 internal nuclei form feedback circuits w/ cerebral cortex. Motor control, behaviour switching, learning, reward.

40
Q

Limbic system

A

Collection of nuclei grouped for location. Hippocampus & amygdala

41
Q

Hippocampus

A

Memory and spatial navigation

42
Q

Amygdala

A

Emotional valence and importance of stimuli

43
Q

What’s involved in protecting nervous system?

A

Meninges, CSF, blood-brain barrier

44
Q

Meninges

A

3 membranes protecting CNS

45
Q

What are the 3 membranes of the meninges?

A

Dura mater, arachnoid mater and Pia mater

46
Q

Dura mater

A

Outermost membrane closest to skull, tough in elastic surrounding CNS, contains large blood vessels

47
Q

Arachnoid mater

A

Appearance & consistency of spider web, no space between dura, impermeable to fluid

48
Q

Pia mater

A

Thin membrane adheres close to brain surface
Separated from arachnoid by space filled w/ CSF
Many blood vessels

49
Q

Cerebrospinal fluid is produced by what?

A

Choroid plexus

50
Q

Where is choroid plexus?

A

In the ventricles

51
Q

What space does CSF fill?

A

Sub-arachnoid space and ventricles

52
Q

Functions of CSF

A

Cushions brain and carries metabolic waste from brain to bloodstream

53
Q

Ventricles

A

4 interconnected cavities in core of brain continuous with central canal of spinal cord & sub-arachnoid space and filled with CSF

54
Q

Blood-brain barrier

A

Restricts entry of macromolecules into brain and shields brain from abnormal variations in ionic composition and potentially toxic molecules

55
Q

What can pass freely into brain?

A

Lipids and water

56
Q

What do tight junctions between endothelial Cells & capillaries restrict?

A

Entry of macromolecules to brain

57
Q

Are astrocytes involved w/ BBB?

A

No - but they regulate blood flow

58
Q

T/F - brain has low metabolic demand

A

False

59
Q

What supplies blood to brain and spinal cord?

A

Internal carotid and vertebral arteries

60
Q

Circle of Willis

A

Arterial ring in blood supply to brain that helps maintain supply if major supplies blocked.

61
Q

What distributes blood supply in brain?

A

Anterior cerebral artery
Middle cerebral artery
Posterior cerebral artery

62
Q

What can cause local damage in brain tissue?

A

Stroke

63
Q

How do we study single neuron extracellularly?

A

Electrode in extracellular space detects APs as spikes

64
Q

Advantages of extracellular recordings

A

Invasive but little damage to cells

Easy to maintain stable recordings and can record for long periods

65
Q

Disadvantages of extracellular recordings

A

Expensive equipment
Difficult to determine how many cells recording from
Difficult to determine exact cell type
Can’t get info about properties of individual cells