6. Head and Neck p327-333 (Mouth, Thyroid, Parathyroid) Flashcards

1
Q

Juvenile Nasal Angiofibroma (4)

A

Male teenager with nosebleeds. Obstruction is a common symptom.
Mass centered on the sphenopalatine foramen.
Expansion of the pterygopalatine fossa.
Very vascular, angiogram will blush.
Primary vascular supply from ascending pharyngeal artery and/or internal maxillary artery

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2
Q

Antrochoanal polyp (6)

A

Seen in 30-40s, with nasal congestion and obstructive symptoms.
Arises within the maxillary sinuses and passes through and enlarges the sinus ostium (or accessory ostium).
“Widening of the maxillary ostium”.
No associated bony enlargement of the sinus.
Polyp extends into the nasopharynx.
Basically a large inflammatory polyp with a thin stalk arising from the maxillary sinus.

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3
Q

Inverting papilloma (5)

A

Uncommon tumour with distinctive imaging features.
Classic location is lateral wall of the nasal cavity, most frequently related to the middle nasal turbinate.
Impaired maxillary drainage is expected.
Focal hyperostosis at the tumour origin.
MRI: “cerebriform pattern”, sort of looks like brain on T1 and T2.
10% harbour a squamous cell cancer.

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4
Q

Esthesioneuroblastoma (4)

A

Neuroblastoma of olfactory cells, starts at cribriform plate.
Classically dubbbell appearance, growth into the skull and down into sinuses, waist at the cribriform plate.
Often cysts in the mass.
Octreotide scan positive, as it’s neural crest origin.

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5
Q

Squamous cell/SNUC (6)

A

Squamous is the most common head and neck cancer.
Maxillary antrum is most common location.
Highly cellular, and therefore low on T2.
Relatively little enhancement compared to other sinus masses.
SNUC (undifferentiated squamous cell) is more aggressive version of regular squamous cell cancer. Massive and seen more in the ethmoid air cells.

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6
Q

Epistaxis (5)

A

Usually idiopathic, can be iatrogenic.
Most common location is anterior septal area (Kiesselbach plexus), but because these are anterior they tend to be easier to manually compress.
Posterior ones are less common but tend to be the ones that bleed uncontrollably and need angio.
Most cases are given a trial of nasal packing before IR.
Main supply to the posterior nose is the sphenopalatine artery (terminal internal maxillary artery), tends to be first target.
Variant anastamosis between ECA ad ophthalmic artery is important, don’t want to embolise the eye.

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7
Q

Floor of mouth dermoid/epidermoid (2)

A

“Sack of marbles” - fluid sac with globules of fat.
Typically midline

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8
Q

Ranula (4)

A

Mucous retention cyst.
Typically lateral.
Arise from sublingual gland/space.
“plunging” once it’s under the myelohyoid muscle.

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9
Q

Torus palatinus (3)

A

Normal variant. Bony exostosis that comes off hard palate in midline.
Classic Hx of dentures not staying in

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9
Q

Sialolithiasis (4)

A

Stones in salivary ducts.
Most comonly in the submandubilar gland (wharton’s).
Can lead to infection (Sialadenitis)
Chronic obstruction can lead to fatty atrophy of the gland.

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10
Q

Odontogenic infection (5)

A

Can be dental or peridontal in origin.
Infection is more common from an extracted tooth than an abscess involving intact tooth.
Attachment of the myelohyoid muscle to the myelohyoid ridge dictates spread of infection to the sublingual and submandibular spaces - above the myelohyoid line (anterior submandibular teeth) goes to sublingual space, below the myelohyoid line (second and third molars) goes to the submandibular space.
Odontogenic abscess is commonest masticator space “mass” in adults.

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11
Q

Ludwig’s angina (2)

A

Agressive cellulitis in the floor of the mouth, gas forming.
Most cases start with orthodontic infection.

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12
Q

Osteonecrosis of the mandible (3)

A

Related to prior radiation, licking radium paint brush, or bisphosphonate treatment.

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13
Q

Cancer (mouth) (3)

A

Squamous cell cancer is most common.
Older - smoking and drinking. Younger - HPV.
HPV related SCCs tend to present with large, necrotic, level 2a nodes (NOT a brachial cleft cyst).

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14
Q

Thyroglossal duct cyst (3)

A

Can occur anywhere between the foramen cecum (base of tongue) and thyroid gland.
Usually found in midline at or above the hyoid.
Looks like thin walled cyst.

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15
Q

Thyroid anatomy (4)

A

Butterfly shaped gland with 2 lobes, connected by an isthmus.
Descends from the foramen cecum at anterior midline base of the tongue, along the thyroglossal duct.
Posterior nodular extension of the thyroid (Zuckerkandl tubercle) helps give a location of the recurrent laryngeal nerve (medial to it)

16
Q

Thyroid nodules (4)

A

Usually seen on US. Very common and almost never cancer.
Suspicious features
- more solid
- calcifications (microcalcifications are a buzzword for papillary thyroid cancer)
Comet tail artefact is seen in colloid nodules.
Cold nodules on I-123 scans are 15% malignancy risk.

17
Q

Thyroglossal duct cyst (5)

A

Can occur anywhere between foramen cecum (base of tongue) and the thyroid gland.
They are usually found in the midline at above the hyoid.
Looks like a thin walled cyst.
Can get infected.
Can rarely have a papillary thyroid cancer (if you cancer (if you see an enhancing nodule)

18
Q

Ectopic and lingual thyroid (5)

A

Similar to thyroglossal duct cyst, found anywhere from base of tongue to central neck.
Most common location (90%) is the tongue base (lingual thryroid).
Looks hyperdense due to iodine content (just like normal thyroid gland).
Sometimes the actual thyroid can be absent.
3% risk of malignant transformation.

19
Q

Goitre (4)

A

Thyroid is too big.
Low iodine in developing world, multinodular goitre or graves in the West.
Can compress the oesophagus or trachea.
Often asymmetric, one lobe bigger than the other

20
Q

Graves (5)

A

Autoimmune disease causing hyperthyroidism (most common cause in West).
Primary from an antibody directed at the TSH receptor.
Actual TSH level is low.
Gland will be enlarged and hot on doppler.
- Graves orbitopathy: Spares tendon insertions, doesn’t hurt unlike pseudotumour. Increased intra-orbital fat.
- Nuclear medicine: Increased uptake of I-123 by usually 50-80%. Visualisation of pyramidal lobe is accentuated.

21
Q

Hashimotos (4)

A

Commonest cause of goitrous hypothyroidism in the US.
Autoimmune disease causing hyper, then hypothyroidism as the gland burns out.
Increased risk of primary thyroid lymphoma.
Associated with anti-TPO and anti-thyroidglobulin antibodies.
Ultrasound: heterogenous giraffe skin appearance, or uniform hyperechoic nodules, actually regenerative nodules.

22
Q

Level 6 “Delphian” nodes (3)

A

Nodes around the thyroid in the front of the neck.
Can commonly see them enlarged with Hashimotos.
On multiple choice tests, a sick looking level 6 node is a laryngeal cancer met.

23
Q

Subacute Thyroiditis/DeQuervains Thyroiditis (5)

A

Female with painful thyroud after URTI.
Similar subtyoe in pregnant women, typically painless.
Hyperthyroidism, then hypothyroidism.
After the URTI, the gland recovers to normal.
Radiotracer uptake is decreased during the acute phase.

24
Q

Reidel’s thyroiditis (6)

A

IgG4 associated disease.
Seen in women in their 40-70s.
Thyroid is replaced by fibrous tissue and diffusely enlarges, causing compression of adjacent structures (dysphagia, stridor, vocal cord palsy).
US: decreases vascularity.
Uptake scan: decreased values.
MRI is dark on all sequences.

25
Q

Acute suppurative thyroditis. (3)

A

Actual bacterial infection of the thyroid.
Possible to develop thyroid abscess in this situation.
Infection in kids may start in a 4th branchial cleft anomaly (usually on the left), travel via a pyriform fistula and then infect the thyroid.

26
Q

Colloid nodules (5)

A

Super common, suspcious features include:
- microcalcifications
- increased vascularity
- solid size >1.5cm
- cold on nuclear uptake scan
Comet artefact is a buzzword.

27
Q

Thyroid adenoma (3)

A

Look like solid colloid nodules on US.
Can be hyperfunctioning (hot on uptake scan).
Usually if it’s hyperfunctioning, background thyroid is colder than normal.

28
Q

Thyroid cancer (5)

A

4 main subtypes
- Papillary
- Follicular
- Medullary
- Anaplastic
- Hurthle cell (variant of follicular)

29
Q

Papillary thyroid cancer (4)

A

Commonest.
“Microcalcifications” is buzzword and key finding in cancer and nodes.
Mets via lymphatics.
Excellent prognosis overall, responds well to I-131

30
Q

Follicular thyroid cancer (3)

A

Second commonest subtype.
Mets haematogenously to bones, lung, liver.
Survival is OK, responds to I-131

31
Q

Medullary thyroid cancer (5)

A

Uncommon.
Associated with MEN II
Calcitonin production is a buzzword.
Tendency towards local invasion, lymph nodes and haematogenous spread.
Doesn’t respond to I-131.

32
Q

Anaplastic thyroid cancer (3)

A

Uncommon, seen in elderly and previous radiation treatment.
Rapid growth, primarily lymphatic spread.
Doesn’t respond to I-131

33
Q

Hurthle cell thyroid cancer (4)

A

Uncommon. Variant of Follicular.
Seen in elderly.
Doesn’t take up I-131 as well as normal follicular.
FDG-PET most useful for surveillance.

34
Q

Thyroid mets (5)

A

“Microcalcifications” in node with papillary.
Nodes are typically bright and hyperechoic, hyperenhancing on CT and T1 bright.
Thyroid cancer is hyper vascular, and mets can bleed a lot, especially in brain.
“Miliary pattern” when it mets to lungs.
Lung mets can be occult on cross sectional imaging, and only seen on whole body scintigraphy.
If you have diffuse lung mets, treating with I-131 can cause pulmonary fibrosis.

35
Q

Parathyroid - normal anatomy (3)

A

4 parathyroid glands, located posterior to the thyroid.
Superior 2 are from the 4th branchial pouch, inferior 2 are from the 3rd branchial pouch.
Inferior 2 are more likely to be in an ectopic location

36
Q

Parathyroid adenoma (4)

A

Most common cause of hyperparathyroidism.
US: Hypoechoic lesions posterior to the thyroid.
CT: 4D scan can show early wash in and delayed wash out.
NM: Dual phase sestamibi +/- I-123 or pertechnate.
Sestamibi imaging depends on mitochondrial density and blood flow

37
Q

Parathyroid carcinoma (2)

A

Uncommon, 1% of hyperparathyroidism.
Imaging looks like adenoma, only differentiator is potential invasion of adjacent structures or cervical lymphadenopathy