6. Development of Digestive System Flashcards
Summary of Digestive System Development
Head fold, lateral folding, tail fold of embryo creates a gut tube with foregut, mudgut and hindgut regions
ENDODERM: Epithelium of the gut tube (mesenteries)- liver, gall bladder and pancrease all develop as outgrowths of the endoderm from distal foregut, with CT elements from mesoderm
MESODERM: Smooth muscle, CT, peritoneum
ECTODERM: Enteric Nervous system from neural crest from ectoderm?
PHARYNX- explain the development of the pharyngeal pouches
Pharyngeal Pouches- lateral outpockets of the pharynx endoderm.
First: Middle ear cavity and the eustachian (auditary tube)
Second: Palatine Tonsil area
Third: Inferior parathyroid and thymus
Fourth: Superior parathyroid, thyroid C cells (make calcitonin)
PHARYNX- explain the development of the pharyngeal arches
Pharyngeal (branchial) arches appear during the 4th & 5th weeks on the ventral side of the pharyngeal gut.
They are the mesenchymal tissue surrounding the pharyngeal pouches (overlying CT of the pouches)- mesenchyme = mesoderm derivative
1st arch= cartilage model of the mandible, two auditory ossicles
2nd arch = one auditary ossicle, styloid process of temporal bone, part of hyoid bone
3rd arch = most of hyoid bone
4th & 6th arches = cartilages of the larynx.
THYROID
Ventral Outgrowths of the pharyngeal ENDODERM -> Thyroid
Thyroid- develops from endoderm of the tongue, connected by the thyroglossal duct to the tongue during development.
- Between the 1st and secondpouches you get the outgrowth which is the thyroid gland, at the junction between anterior 2/3 and posterior 1/3 of the tongue.
Migrates a significant distance down the front.
THYROID
What is the name of the remanent of the thyroglossal duct?
What are some errors which can occur in the development of the thyroid?
Foramen cecum = remnant of site of origin of the thyroglossal duct
Errors
thyroglossal cyst- patent thyroglossal duct, may have some cysts growing off it
Fistula- may open into the neck
What are some otther ventral outgrowths of the PHARYNX?
RESPIRATORY DIVERTICULUM
How does the Respiratory Diverticulum form?
Oesophageal ridges fuse to form tracheoesophageal septum, which separates trachea from oesophagus. Larynx remains in communication with laryngopharynx at the laryngeal orifice. Branching begins => lung buds.
Respiratory diverticululm gives rise to the:
Larynx
Trachea
Lungs (branching morphogenesis)
Errors in respiratory diverticulum development
Proximal Atresia with distal tracheosophageal fistula- most common error, the upper portion of the oesophagus ends in a blind pouch, and the lower segment forms a fistula with the trachea
Peritoneal Cavity Development
Intraembryonic Coelom = ventral body cavity
Begin as cavities in the lateral plate mesoderm, initially continuous with the extraembryonic coelom
Lateral folding- cavities merge on midline forming the ventral body cavity
Peritoneum- visceral and parietal
There are two layers of the lateral plate mesoderm which contribute to the peritoneum
- Splanchnic layer: covers organs -> visceral peritoneum
- Somatic layer: covers body cavity wall -> parietal peritoneum
Describe the development of the mesenteries of the GUT
The primitive gut is enveloped by a mesentery that has a dorsal and ventral aspect.
The DORSAL MESENTARY contains nerves, arteries, veins and lymphatics: it is a double layer of peritoneum from the abdominal wall to the gut . The dorsal mesentery is not lost but in some parts it comes to lie against the abdominal wall.
The VENTRAL MESENTERY of the midgut & hindgut breaks down- but the foreguts is maintained.- the liver grows into the ventral mesentary of the stomach.
Intraperitoneal vs. Retroperitoneal Organs
Organs that keep their dorsal mesentary are INTRAPERITONEAL
- attached to the posterior abdominal wall.
Organs that lose it by contacting posterior abdominal wall= secondarily RETROPERITONEAL
= duodenum (except for the proximal segment), pancreas, ascending and descending colon
Explain the neurovascular supply of the FOREGUT
Foregut derivatives in the abdomen: Oesophagus, stomach, first part of the duodenum (superior, descending), liver, gallbladder, spleen, superior portion of the pancreas
Coelic Artery
Various veins which drain directly or indirectly into the hepatic portal vein
Coeliac ganglion and plexus- autonomic innervation
Coeliac lymph nodes - lymphatic drainage (liver is the exception)
Describe the rotation of the stomach and its mesenteries
Spleen develops in the DORSAL mesentary,
Liver in the VENTRAL mesentary of the stomach
90 degreee clockwise rotation of the stomach (viewed from anterior and superior aspect) accounts for location of spleen to left and liver to the right
- and left vagus nerve mainly forming the ANTERIOR VAGAL TRUNK (rotates anteriorly)
- and right vagus nerve mainly forming hte posterior vagal trunk (rotates posteriorly)
Mesenteries of the Stomach, Liver and Spleen
Ventral Mesentery - MESOGASTRIUM - forms the lesser omentum, falciform ligament
Dorsal Mesentery- greater omentum, gastrosplenic ligament, splenorenal ligament