2. Stomach Flashcards

1
Q

What are the functions of the stomach

A
  • Stores ingested food- distension
  • Mechanical digestion- peristaltic contraction churns contents
  • Initial chemical digestion of proteins- secretion of gastric juice including acid and pepsinogen (→ pepsin, a protease)
  • Secretion of intrinsic factor and gastroferritin for absorption of vitamin B12 and iron in more distal gut
  • Regulated movement of food into the duodenum
  • Endocrine function (eg. Gastrin)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Name the anatomical regions of the stomach

A
  • Cardiac
  • Fundus
  • Body
  • Pyloric- antrum and canal
  • Physiology- orad and caudad areas
  • Histology- different epithelium characteristics and secretory products in different areas
  • Lower oesophageal sphincter (cardiac sphincter)
  • Pyloric sphincter
  • Cardiac notch
  • Angular notch
  • Greater Curvature
  • Lesser Curvature
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Describe the smooth muscle layers of the stomach

A

3 Layers- outer longitudinal, middle circular, inner oblique
Longitudinal layer- incomplete anteriorly and posteriorly
Oblique layer- incomplete along curvatures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Describe the internal anatomy of the stomach

A

The mucosal layer (both mucosa & submucosa) is quite folded, and these are known as gastric folds or rugae. These folds allow stomach to expand; if its distended then the folds disappear

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Describe the surface anatomy of the stomach.

A
  • Right Upper quadrant
  • Right Lower Quadrant
  • Left Upper Quadrant
  • Left Lower Quadrant
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Name the 9 regions of the abdomen

A

Right hypochondrium Epigastrium Left hypochondrium
Right lumbar (lateral/flank) Umbilicus Left lumbar (lateral/flank)
Right iliac fossa (inguinal/groin) Hypogastrium Left iliac fossa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Where is the superior plane located?

A

Transpyloric at L1/L2 discs //subcostal plane (lowest part of the ribs)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Where is the inferior plane located?

A

Interspinous (ASIS) // intertubercular (iliac tuberculum)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Where is the vertical plane located?

A

Semilunar (six pack) // midlinguinal // midclavicular

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

In which quadrants is the stomach located?

A

Stomach is located primarily in the upper left quadrant, but it extends into the right quadrant.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

In which 9 regions is the stomach located

A

It is located in the left hypochondrium and epigastric regions
Stomach shape variable, but ends are relatively fixed.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Where is the Lower Oesophageal Sphincter Located? what is an alternative name for it?

A

(cardiac sphincter) in on the left side of vertebra T11; just interolateral (left side) of the xiphoid process and near the left 7th sternocostal joint.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Where is the Pyloric Sphincter Located?

A

to right of L1/L2 vertebrae (transpyloric plane)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the peritoneum?

A

The peritoneum is a thin membrane which lines the walls of the abdominal cavity and covers much of the viscera. The parietal peritoneum lines the walls of the cavity and the visceral peritoneum covers the viscera. Between the parietal and visceral layers of peritoneum there is a potential space (the peritoneal cavity). Abdominal viscera either are suspended in the peritoneal cavity by folds of peritoneum (mesenteries) or are outside the peritoneal cavity. Organs suspended in the cavity are referred to as intraperitoneal; organs outside the peritoneal cavity, with only one surface or part of one surface covered by the peritoneum, are retroperitoneal.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the mesentary?

A

peritoneal folds that attach viscera to the posterior abdominal wall. They allow some movemetna dn provide a conduit for vessels, nerves, and lymphatics to reach the viscera. The mesnntary is a large, fan shaped, double layered fold of peritoneum that connects the jejunum and ileum to the posterior abdominal wall.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the lesser omentum? What is it derived from?

A

Lesser omentum, including hepatogastric ligament (along lesser curvature) – derived from ventral mesentery.
• The lesser omentum is the double layer of peritoneum that extends from the liver to the lesser curvature of the stomach and the start of the duodenum.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is the Greater Omentum? From where is it derived?

A

Greater omentum (along greater curvature) and gastrosplenic ligament – derived from dorsal mesentery

**Developmentally, stomach has dorsal and ventral mesenteries- then rotates 90 degrees

• The greater omentum is the large fold of visceral peritoneum that hangs down from the stomach. It runs from the greater curvature of the stomach, passing in front of the small intestines and reflects on itself to ascend to the transverse colon before reaching the posterior abdominal wall.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

The Greater Sac vs. Lesser Sac

A

• Greater sac - most of peritoneal cavity
• Lesser sac – omental bursa – posterior to stomach and lesser omentum
o During developmental rotation you get part of the peritoneal cavity trapped behind the stomach = omental bursa/leser sac

19
Q

What is the Omental (epiploic) foramen?

A

• There is a small opening between the greater and lesser sacs known as the epiploic (omental) foramen, posterior to ‘portal triad’ (bile duct, hepatic portal vein, hepatic artery).

20
Q

Describe these anatomical Relationships of the stomach:

What is-

Anterior

Left and Posterior

Right

Posterior

Inferior

Superior

A
  • Anterior to the stomach = A little bit of the liver, chest wall (lower ribs- rib 6,7,8 and costal cartilages, diaphragm, and anterior wall)
  • Left & Posterior = Spleen!
  • Right = Liver
  • Posterior = Pancreas, kidney/suprarenal glands, abdominal aorta, IVC
  • Inferior = transverse colon & behind that are loops of the small intestine
  • Superior = Heart- left ventricle, diaphragm
21
Q

From which artery are all of the arteries of the stomach derived?

A

All from coeliac artery, directly or indirectly (foregut derivative)

22
Q

What Arteries run along the lesser curvature?

A

L, R gastric aa along lesser curvature
• The Left gastric artery comes directly off the coeliac trunk
• Right gastric artery from the proper hepatic artery (from common hepatic from coeliac trunk)
• Right & left anastamose

23
Q

Which arteries run along the greater curvature?

A

L,R gastroepiploic (gastro-omental) aa along greater curvature => supply the greater omentum
• Right gastroepiploic artery from gastroduodenal artery (which arises from the common hepatic artery or directly from the celiac trunk)
• Left gastroepiploic artery from the splenic artery from the celiac trunk

Short gastric aa to fundus
• From the splenic artery

24
Q

What is the main venous drainage of the GI tract?

A

Portal Vein (hepatic portal vein) through a second set of capillaries in the liver (liver sinusoids), and then to hepatic veins to IVC

25
Q

Stomach veins drain to which main veins?

A

Stomach veins drain to splenic, superior mesenteric, or directly to hepatic portal vein (there is NOT a coeliac vein)

26
Q

R/L gastric veins drain to?

A

Hepatic Portal Vein

27
Q

• L gastroepiploic, short gastric veins drain into ?

A

• L gastroepiploic, short gastric veins drain into the splenic vein => hepatic portal

28
Q

• R gastroepiploic drains into the ?

A

• R gastroepiploic drains into the superior mesenteric vein => hepatic portal

29
Q

List the blood vessels in order through which the blood flows from the heart to the lesser curvature of the pyloric region of the stomach, and back to the heart:

A

Left atrium – left ventricle – arch of aorta – descending aorta – abdominal aorta – coeliac trunk – proper hepatic artery– right gastric artery – capillaries in pyloric region – right gastric veins – hepatic portal vein (nutrient rich, oxygen poor blood) – hepatic sinusoids – hepatic vein – IVC – RA

30
Q

Lymph Nodes of the stomach?

A
  • There are lymph nodes scattered along the greater and lesser curvature of the stomach; pancreosplenic nodes, greater and lesser nodes, pyloric nodes etc => all drain into the coeliac lymph nodes which surround the coeliac trunk
  • Coeliac trunk => intestinal lymph trunk => cysterna chili => thoracic duct => left subclavian => left brachiocephalic
31
Q

Innervation of the stomach

Parasympathetic- what is its other name?

Where are the preganglionic cell bodies located?

A

• Also called craniosacral division of the ANS
o Preganglionics either in cranial cavity or sacrum of the spinal cord
• For the stomach, the preganglionics are located in the medulla of the brainstem

32
Q

What is the path for parasympathetic nerves?

A

• Neuron cell bodies have axons which exit the medulla & are conveyed by the vagus nerves (through neck, thorax and into the abdomen) to the stomach.
• In the thoracic cavity, the vagus nerves form the oesophageal plexus
o Left vagus nerve is on the anterior side & the right vagus nerve ends up mainly going to the posterior aspect of the oesophagus; collectively they form the oesophageal plexus & then the anterior & posterior vagal trunks (on either side of the oesophagus)
• The vagal trunks exit through the diaphragm with the oesophagus at T10
• The vagus nerve runs along the oesophagus & supplies both the midgut & foregut.
• Vagal trunks synapse as intramural ganglion – they can synapse directly onto smooth muscle or glands, or can synapse onto enteric nervous system (ENS). They may also have gastric branches.

33
Q

Innervation of the Stomach!

Sympathetics-

What is it also known as?

Where are the preganglionics located?

What is the route for the nerves!

A

• Also known as the thoracolumbar division of the ANS
o Preganglionic cell bodies in the thoracic & upper lumbar regions: T1-12 & L1-2

• For stomach (foregut derivative) preganglionics mainly located in T6-T9, in the lateral horn of the gray matter of the spinal cord.

  • Through the ventral root, then spinal nerve, then axons peel off to the grey and white rami communicantes (communicating nerves), leading into the sympathetic chain ganglion. But axons do not synapse in these ganglions, they pass through, so (long) preganglionic axons exit anteriorly forming the greater thoracic splanchnic nerve (T6-T9) which pierces the diaphragm with the oesophagus at T10.
  • Greater thoracic splanchnic nerve synapses in coeliac ganglion (solar plexus)
  • Postganglionic axons follow blood vessels to directly innervate smooth muscle, glands, or synapse with the ENS.
34
Q

Which afferent neuronal cell bodies travel with the vagus nerve?

A

• Some travel with vagus nerve (stretch sensitive) for vagovagal reflexes etc
o Stretch sensitive neurons tend to travel with vagus n (both afferent and efferents)

35
Q

Which afferent neuronal cell bodies travel with the sympathetic neurons?

A

• Some travel with sympathetics (pain) except through dorsal root
o Other sensory, generally pain fibres will travel with sympathetics & go to the exact same spinal segments
• Referred pain from stomach: T6-T9 dermatomes (corresponds to spinal cord levels with sympathetics for stomach), especially epigastric region
o Ie. sensory pain fibres from stomach go to T6-T9 segments of spinal cord & may synapse on the same neurons as those from the body wall, so infor from the brain can get confused & stomach pain can be regerred to the epigastric region.

36
Q

Describe Gastric Motility

What are the 3 phases of gastric motility?

A
  • Note: gastric secretions will be covered in histology
  • During fasting, stomach inactive except for a strong contraction once every 1.5 hours- migrating motility complex (MMC), propels residual stomach contents into the duodenum

• During eating: filling, mixing, emptying phases.

37
Q

Describe the filling phase of Gastric motility

A

• Stretch- relaxation of smooth muscle (as stomach stretched, smooth muscle relaxes to allow stomach to fill)
o Intrinsic property of stomach smooth muscle
o Also long reflex mediated relaxation (vagovagal) – vagus nerve picks up the stretch and stimulates relaxation of smooth muscle
• Allows distension of stomach, without increasing tension on wall & intraluminal pressure- up to 1-1.5 L
• Occurs in orad region

38
Q

Describe the Mixing Phase of Gastric Motility

A
  • Peristaltic waves from body to pylorus (caudad region)
  • Food mixed with gastric secretions
  • Physical digesion – semi liquid mixture is chime
  • Note: fundus/superior region doesn’t show much contraction, contractions become larger & more powerful as you approach the pyloric sphincter.
39
Q

Describe the Emptying phase of gastric motilty

A
  • Occurs simultaneously with the mixing phase
  • Pyloric sphincter relaxes periodically
  • Peristaltic wave in pyloric region squeezes a small volume of chyme into the duodenum
  • Stomach may take 2-4 hours to empty
  • Allows neutralization of acidic chime in duodenum, and adequate time for digestion and absorption in small instestine
40
Q

Describe the control of gastric motility

A
  • 3 phases of gastric motility: filling, mixing, emptying
  • 3 phases of control: cephalic, gastric, intestinal
  • Neural & hormonal control- local neural network and some paracrine factors as well
41
Q

Describe the cephalic phase of regulation

A

• Sight, smell, thought of food
• Food in mouth
• Vagus nerve mediated – increase motility & secretion
• Acetylcholine or gastrin releasing peptide (GRP), released by intramural neurons, stimulates release of gastrin & histamine
o Gastrin is a paracrine hormone that affects the stomach lining
• Ach, Gastrin & histamine have a synergistic effect on gastric (acid HCl-) secretion

42
Q

Describe the Gastric Phase of regulation

A

• Initiated by food entering & distending stomach -> mechanoreceptors detect the stretch
• Local (enteric NS) & vagus n mediated reflexes
o => increase gastrin & histamine release & thus increase acid secretion

43
Q

Describe the intestinal phase of regulation

A

• Chyme in duodenum inhibits gastric secretion & motility
• Slows stomach emptying as chime doesn’t enter too fast
• Cholecystokinin, secretin, gastric inhibitory peptide (hormones) released by duodenum => inhibits gastric secretions
o Number of hormones produced by enteroendocrine cells