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Boards Pharm 01: Antimicrobials > 6. Antiparasitics > Flashcards

6. Antiparasitics Flashcards

1
Q

Pyrimethamine - Clinical Use

A

Toxoplasmosis

Plasmodium falciparum - Malaria

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2
Q

Suramin - Clinical Use

A

Trypanosoma brucei - African Sleeping Sickness

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3
Q

Melarsoprol - Clinical Use

A

Trypanosoma brucei - African Sleeping Sickness

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4
Q

Nifurtimox - Clinical Use

A

Trypanosoma cruzi - American Sleeping Sickness

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5
Q

Sodium Stibobluconate - Clinical Use

A

Leichmaniasis

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6
Q

Chloroquine - MOA

A

Blocks Plasmodium heme polymerase

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7
Q

Chloroquine - Clinical Use

A

Plasmodium spp. - Malaria

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8
Q

Chloroquine - Toxicities

A

Retinopathy

- G6PD hemolysis

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9
Q

Mefloquine - MOA

A

Blocks Plasmodium heme polymerase

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10
Q

Mefloquine - Clinical Use

A

Treatment and prophylaxis of Plasmodium spp. - Malaria

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11
Q

Quinine - MOA

A

Blocks Plasmodium heme polymerase

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12
Q

Quinine - Clinical Use

A

In combination with Pyrimethamine/Sulfonamide for Resistant Plasmodium spp. - Malaria

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13
Q

Anihelminthic Therapy - MOA

A

Immobillize helminths

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14
Q

Antihelminthic Therapy - Available Drugs

A 
Mebendazole
Albendazole
Pyrantel pamoate
Ivermectin
Diethylcarbamazine
Praziquantel
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15
Q

Anti-Nematode (round worm) Therapy

A

GI infections

  • bendazoles or pyrantel pamoate
  • “Worms and the intestines are BENDy, treat with meBENDazole”
  • Strongyloides can also use Ivermectin
  • “Ivan the Strong man”

Tissue

  • Mostly Diethylcarbamazine
  • Ochocerca volvulus use Ivermectin
  • “IVERmectin for rIVER blindness”
  • Dracunculus use Niridazole
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16
Q

Anti-Cestode (tape worm) Therapy

A

Mostly Praziquantel

  • -bendazoles for cysts
  • —- neurocysticercosis of Taenia solium
  • —- Echinococcus granulosus (liver cysts)
17
Q

Anti-Trematode (fluke) Therapy

A

All Praziquantel

18
Q

Antiprotozoan Therapy - Available Drugs

A 
Pyrimethamine
Suramin
Melarsoprol
Nifurtimox
Sodium stibogluconate
Chloroquine
Mefloquine
Quinine

Boards Pharm 01: Antimicrobials (7 decks)

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