5.3.2 Carlsson

Question 1

Aim

Answer 1

A review on the evidence for and against the dopamine hypothesis, explore the role of other nts and explore new antipsychotics (especially for treatment resistant).

Question 2

Sample

Answer 2

• Lit review
• 33 studies
• 1 unpublished
• 14 he took part in

Question 3

1) The dopamine hypothesis revisited

Answer 3

• PET scans show amphetamines (dopamine agonists) enhance sz symptoms in people with sz more than controls especially in basal ganglia
• This is seen as too simplistic

Question 4

2) Beyond dopamine

Answer 4

• Focus on glutamate
• PCP induces sz symptoms as its an NMDA antagonist (reduces glutamate) - Lodge et al

Question 5

3) Glutamatergic control of dopamine release