5.1.4 Hormonal communication Flashcards

1
Q

What is the the difference between endocrine and exocrine?

A

Exocrine - secretion of chemical outside of blood e.g. digestive enzymes
Endocrine - secretion of chemical inside of blood e.g. hormones

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2
Q

What hormones does the pituitary gland secrete? Give their functions

A
  • Growth hormone: controls growth of bones and muscles
  • ADH: increases reabsorption of water in kidneys
  • Gonadotrophin’s: control development of ovaries and testes
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3
Q

What hormone does the adrenal gland secrete? Give it’s function

A
  • Adrenaline: increases heart, breathing rate and raises blood sugar level
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4
Q

What hormone does the pineal gland secrete? Give it’s function

A
  • Melatonin: affects reproductive development and daily cycles e.g. sleep cycle
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5
Q

What hormone does the thyroid gland secrete? Give it’s function

A
  • Thyroxine: controls rate of metabolism
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6
Q

What hormone does the thymus secrete? Give it’s function

A
  • Thymosin: promotes production and maturation of white blood cells
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7
Q

What hormones does the pancreas secrete? Give their functions

A
  • Insulin: converts glucose to glycogen in the liver
  • Glucagon: converts glycogen to glucose in the liver
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8
Q

What hormones does the ovaries secrete? Give their functions

A
  • Oestrogen: controls ovulation and secondary sexual characteristics
  • Progesterone: prepares the uterus lining for receiving an embryo
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9
Q

What hormone does the testes secrete? Give it’s function

A
  • Testosterone: controls sperm production and secondary sexual characteristics
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10
Q

Why can steroid hormones pass through the cell membrane?

A

They are lipid soluble

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11
Q

How do steroid hormones work?

A
  • Bind to steroid hormone receptors within cytoplasm or nucleus
  • Hormone-receptor complex acts as a transcription factor which promotes or inhibits transcription of specific gene
  • e.g. oestrogen
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12
Q

Why can non-steroid hormones not pass though cell membrane?

A

Hydrophilic so will be repelled by fatty acids

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13
Q

How to non-steroid hormones work?

A
  • Bind to specific receptors on cells surface membrane
  • Triggers cascade reaction mediated by secondary messengers
  • e.g. adrenaline
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14
Q

Differences between hormonal and neuronal communication?

A

Hormonal
- Slower transmission and response
- Hormones travel to all parts of body
- Widespread response
- Long lasting response
- Effect permanent and irreversible

Neuronal
- Faster transmission and response
- Hormones travel to specific parts of body
- Localised response
- Short-lived response
- Effect temporary and reversible

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15
Q

What is the adrenal cortex?

A
  • Outer region of the gland
  • Produces hormones vital to life e.g. cortisol and aldosterone
  • Steroid hormones
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16
Q

What is the adrenal medulla?

A
  • Inner region of the gland
  • Produces non-essential hormones e.g. adrenaline and noradrenaline
  • Non-steroid hormones
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17
Q

What is the function of adrenaline?

A
  • Increases heart rate
  • Increases blood glucose concentration levels
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18
Q

What is the function of noradrenaline?

A
  • Works with adrenaline in response to stress
  • Increases heart rate
  • Widens pupils
  • Widens air passages in lungs
  • Narrows blood vessels in non-essential organs
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19
Q

What is the function of aldosterone?

A

Controls blood pressure by maintaining balance between salt and water concentrations

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20
Q

What is the function of androgens?

A

Male and female sex hormones important in menopause

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21
Q

What is the function of cortisol?

A

Regulates carbohydrate metabolism, blood pressure and cardiovascular function

22
Q

How is the pancreas an exocrine gland?

A

Produces digestive enzymes (trypsin, lipase and amylase) and pancreatic juice which are released via pancreatic duct

23
Q

How is the pancreas an endocrine gland?

A

Produces hormones (insulin and glucagon) which are released into blood

24
Q

Which cells in the Islets of Langerhans produce and secrete glucagon?

25
Which cells in the Islets of Langerhans produce and secrete insulin?
β cells
26
__ cells are larger and more numerous
Alpha
27
What colour are β cells stained?
Blue
28
What colour are α cells stained?
Pink
29
What is the endocrine tissue of the pancreas?
Islets of Langerhans (lighter stained)
30
What is the exocrine tissue of the pancreas?
Pancreatic acini (darker stained)
31
What is glycogenolysis?
Breakdown of glycogen into glucose
32
What is gluconeogenesis?
Production of NEW glucose from non-carbohydrate sources e.g. lipids and amino acids
33
What is glycogenesis?
Production of glycogen from glucose
34
What happens when blood glucose concentration is too high?
β cells detect change and secrete insulin
35
How does insulin lower blood glucose levels?
- Increased cellular respiration - Increased glycogenesis - Increased conversion of glucose into fats - Increased absorption of glucose into cells
36
What happens when blood glucose concentration is too low?
α cells detect change and secrete glucagon
37
How does glucagon raise blood glucose levels?
- Increased glycogenolysis - Increased gluconeogenesis (converting amino acids and glycerol into glucose)
38
Which cells have insulin receptors?
All cells except RBCs
39
Which cells have glucagon receptors?
Liver and fat cells
40
What is the mechanism of insulin secretion?
1) Blood glucose above normal levels 2) Glucose enters via carrier protein (GLUT-2) 3) Respiration using glucose occurs and ATP produced 4) ATP sensitive K+ channel closes 5) Depolarisation occurs 6) Voltage gated Ca2+ channels open 7) Increased Ca2+ causes secretory vesicles to release insulin via exocytosis 8) K+ channel re-opens and cell back to resting state
41
What is type 1 diabetes?
β cells unable to produce insulin
42
What is type 2 diabetes?
Cannot effectively use insulin - β cells do not produce enough insulin - Body cells do not respond to insulin
43
What causes type 1 diabetes?
Autoimmune response attacking β cells
44
What causes type 2 diabetes?
- Excess body weight - Physical inactivity - Excess overeating of sugars
45
What are the symptoms of diabetes?
- Glucose present urine - Excessive need to urinate - Excessive thirst - Weight loss - Blurred vision
46
What is the treatment for type 1 diabetes?
Regular injections of insulin
47
What is the treatment for type 2 diabetes?
- Reducing the intake of carbohydrates and sugars - Exercise - Medicine
48
What are the benefits of using GM bacteria to produce insulin rather than animals?
- Pure form so less risk of allergic reaction - Produced in higher quantities - Cheaper - More ethical
49
What are the problems with a pancreas transplant?
- Demand outweighs availability - Long term immunosuppressant drugs required so person susceptible to infection
50
What is potential future treatment for diabetes and what are the benefits?
Stem cells - Unlimited source of β cells - Reduced likliehood of rejections - Injections of insulin no longer required