5.1.2 - Reproduction in Mammals

Question 1

Sexual reproduction in mammals - mechanisms to maximise success

Answer 1

• Internal fertilisation → increase chance that gametes will meet
• Implantation of the embryo into the uterine wall + internal development of embryo → higher chance of survival
• Pregnancy → protects the developing young from the environment + nourishes embryo through placental connection
• Birthed only once it is matured enough to be able to survive (viable)

Question 2

Hormones

Answer 2

Def: Chemical substances that coordinate physiological functions

Coordinates the reproductive cycle to ensure greater reproductive success:
* Pituitary gland - the master gland. It releases hormones to stimulate/inhibit other organs to release/stop hormones.
* Sex hormoes - specifially affect the growth

Question 3

Sex hormones

Answer 3

• Androgen
• Testosterone
• Oestrogen
• Progestogen
• Progesterone

Question 4

Hormones in the female reproductive cycle

Answer 4

Gonadotropic hormones released by pituitatry glands:
* Follicle stimulating hormones: stimulate maturation of follicles in the ovaries of females
* Luteinising hormones - stimulates the final maturation of one ovarian follicle → stimulates ovulation + stimulates the onset of the luteinising phase
* In males, it stimulates secretion of testosterone.

Ovary secretes oestrogen and progesterone

Question 5

Follicle

Answer 5

A small, fluid-filled sac in the ovary that contains one immature egg
- Follicle cells secrete fluid to push the egg inside it to one side of the follicle
- Graafian follicle: dominant follicle that moves to the surface of the ovary and creates a bulge (this is the one that will cause ovulation)

Question 6

What is regulated by hormones on the female reproductive cycle

Answer 6

• Ovarian cycle: development of the female gametes/ova in the ovaries.
• Menstrual cycle: the uterus is prepared for implantation of a fertilised egg each cycle. If fertilisation does not take place, the levels of oestrogen and progesteron decrease, resulting in the lining of the uterus tearing away accompanied by bleeding. AKA menstruation
• Maintenance of pregnancy
• Preparation for and maintenance of lactation

Question 7

Ovarian cycle

Answer 7

• Growth and maturation of an oocyte in preparation for fertilization and reproduction
• Consists of follicular phase, ovulation, and luteinising phase

Question 8

Folliular phase

Answer 8

• Follicle cells secrete fluid, pushing the egg to one side of the follicle.
• The enlarged dominant follicle moves to the surface of the ovary and creates a bulge. The follicle that does this is called the Graafian follicle
• The Graafian follicle bursts, releasing the egg/ova - ovulation
• The female ovum is now viable for 12-24 hours
• After ovulation, the egg has been released from the follicle, and is known as the corpus luteum

Question 9

Graafian follicle

Answer 9

Mature follicle that moves to the surface of the ovary and forms a bulge to release the egg

Question 10

Luteinising phase

Answer 10

• Starts after ovulation, lasts 14 days
• Luteinising hormone production surges due to secretion of oestrogen by follicular cells → ovulation
• Corpus luteum secretes progesterone which builds up uterine wall lining → body prepared for pregnancy
• Main secretor of progesterone until placenta has formed

Question 11

Menstrual cycle

Answer 11

• Begins with menses (uterine lining sheds, causing bleeding)
• New endometrial lining forms over 5-12 days after menstruation → preovulation phase
• Ovulation occurs in the ovaries 13-15 days after the start of menstruation
• After ovulation, the enlarged corpus luteum releases progesterone and oestrogen
• Progesterone acts on target cells in the uterus, preparing the endometrium for implantation of the fertilised ovum and pregnancy.

Cells start forming in the endometrium lining. Oestrogen starts the development of the endotrium wall (cell division). The developing and thickness (blood vessels, mucus ) is by progesterone.

Question 12

Placenta in humans

Answer 12

Direct access to the bloodstream - no maternal cells. Unrestricted access can cause intense fatigue, high blood pressure, plecampsia. Severing the fetus can cause a haemmorage.

Question 13

Oocyte

Answer 13

Unfertilised egg cell. Contained within a follicle until ovulation

Question 14

Male reproductive cycle

Answer 14

• Follicle stimulating hormone causes the Sertoli cells of the tests to begin the process of spermatogensis (sperm production)
• Luteinising hormone triggers the production of testosterone from the Leydig cells - development of secondary male characteristics.

As spermatogensis and testosterone production increases - Sertoli cells produce inhibin to stop FSH and LH production in the pituitary gland

Question 15

Fertilisation

Answer 15

• Oviducts release a fluid that helps sperm swim up the reproductive tract to the uterus (rheotaxis)
• The presence of progesterone and an akaline pH helps the sperm matures so that it can penetrate the egg. These sperm becomes hypermobile.

Question 16

Pituitary gland

Answer 16

• Master gland
• Secretes hormones that stimulate or inhibit other endocrine glands
• Secretes 2 Gonadotropic hormones: follicle-stimulating hormone (FSH) and luteinising hormone (LH)

Question 17

Androgens

Answer 17

• Group of male sex hormones
• Controls development and functioning of male sex organs + secondary sex characteristics
• Present in males and females but higher in males

Question 18

Testosterone

Answer 18

• An androgen
• Facilitates sperm production (spermatogenesis)
• Secreted by testes

Question 19

Oestrogens

Answer 19

• Group of female hormones
• Controls development and functioning of female reproductive system + secondary sex traits
• Higher in female but present in male also
• Secreted by ovary

Functions
In the follicular phase of the ovarian cycle, oestrogen is secreted by cells in the lining of the follicle → production of luteinising hormones surge, causing ovulation

In the menstrual cycle, oestrogen and progesteron maintain the uterine wall. A drop in oestrogen levels thus leads to the shedding of the uterine wall

During pregnancy, oestrogen promotes growth of endometrium

Question 20

Progestogens

Answer 20

Second group of female hormones

Question 21

Progesterone

Answer 21

• An oestrogen hormone
• Stimulates lactation in mammary glands
• Produced by adrenal cortex and gonads normally, but during pregnancy it is synthesised by the corpus luteum
• Maintains the endometrium and builds uterine lining alongside oestrogen, preparing the uterus for implantation and pregnancy
• Development of mucus and growth of blood vessels
• High levels of progesteron prevent uterine contractions

Question 22

3 layers sperm has to cross to fertilise an egg

Answer 22

Corona radiata:
- 1st membrane, sperm has to physically push through
- Corona radiata can release enzymes to help sperm penetrate

Zona pellucida:
- 2nd layer with glycoproteins
- When sperm comes into contact with glycoproteins, acrosome fuses with cell membrane of sperm head, helping the sperm release enzymes that assist its penetration

Plasma membrane:
- When one sperm penetrates the plasma membrane, surface proteins trigger the release of enzymes by the egg that destroy glycoproteins in the zona pellucida and cause electrical charges, preventing other sperm from entering

Question 23

HCG

Answer 23

• Human chorionic gonadotropic hormone
• Starts being secreted by the trophoblast, the outer cells of the blastocyst when implantation occurs (trophoblast will later form the placenta, so it can be said that HCG is produced by the placenta)
• Sustains the corpus luteum until the placenta is fully developed → progesterone and oestrogen levels are maintained → endometrium thickness grows, menstruation does not occur
• Levels rise after conception and continue to rise until 10 weeks in pregnancy.
• Promotes relaxin production, allowing the uterus to relax and accomodate for the growing embryo.

Question 24

How to EXPEL the baby

Answer 24

1. Uterine contraction
2. Cervix dilates (pelvis and cervic muscles must soften)

Question 25

Labour

Answer 25

The process of uterine contractions in which the baby is expelled from the uterus to be born.

Question 26

Alcohol intake impact

Answer 26

Hormone levels

Question 27

Why does a foetus kick?

Answer 27

It is essential for muscular and skeletal growth/development.

Question 28

LH

Lutenising hormone

Answer 28

• Secreted by anterior pituitary gland
• Targeted at the ovaries, to trigger ovulation

Question 29

GnRH

Gonadotropic releasing hormone

Answer 29

• Produced by hypothalamus in the brain
• Stimulates production of FSH and LH
• If oestrogen and progesterone levels high in the blood, GnRH will stop stimulating FSH and LH production because it will take this to mean that ovulation has occurred and there is no longer need to produce FSH and LH

Question 30

Implantation

Answer 30

• Fertilised egg that has begun to undergo cell division as it travells down the fallopian tube implants itself into the endometrium. This is called the blastocyst
• The inner cell mass of the zygote will form the embryo
• Outer cells (trophoblast) will form the placenta
• Once blastocyst is implanted, embryo starts releasing HCG to sustain the corpus luteum’s production of oestrogen and progesterone

Question 31

Hormones involved in birth

Answer 31

Prostaglandins: Starts the process of labour (contraction of uterine walls). Makes uterus more sensitive to oxytocin (main hormone in contractions)

Oxytocins: coordination of the contraction of the smooth muscles of the uterus + softens the cervix so that baby can be born

Relaxin: relaxes the cervic too

What happens to progesterone and oestrogen levels during birth: these hormone levels decrease and cause stronger constractions.

Beta-endorphins: a form of natural pain relief

Adrenaline: end of labour to cause strong contractions that lead to the birth

Prolactin: sitmulates lactation

Question 32

Prostaglandin

Answer 32

• Secreted by the walls of the uterus
• Helps soften cervix and enhance contractions triggedred by oxytocin → baby can be expelled

Question 33

Oxytocin

Answer 33

• Secreted by the pituitary gland
• Stimulates uterine contractions and softening of cervix
• Positive feedback loop: contractions signal the pituitary gland to release more oxytocin, amplifying contractions

Question 34

Relaxin

Answer 34

Another hormone that helps relax the cervix, along with oxytocin and prostaglandin

Question 35

Progesterone and oestrogen role in labour

Answer 35

Drop in progesterone and oestrogen levels cause stronger contractions.
7 month~ Progesterone levels decrease (high levels prevent contractions) while oestrogen continues to increase. This makes the uterus more sensitive to oxcytocin.

Question 36

Beta-endorphins

Answer 36

Act as natural pain relief

Question 37

Adrenaline

Answer 37

• Released at the end of labour to cause strong contractions that lead to birth

Question 38

Prolactin

Answer 38

• Secreted by the pituiary gland (like oxytocin)
• Stimulate production of milk in the breasts by acting on the mammary glands
• Ensures milk is available for breastfeeding as soon as the child is born