510-6

Question 1

Name 4 components of saliva.

Answer 1

Amylase, Lingual lipase, and immunoglobulin A (antibacterial/antiviral), and SLPI (potent antimicrobial)

Question 2

Name the component in saliva that aids in wound closure.

Answer 2

Histatins

Question 3

How much saliva is secreted each day?

Answer 3

1 to 1.5 Liters

Question 4

Describe 2 consequences of the autonomic innervation of the salivary response.

Answer 4

Parasympathetic - via AcetyCholine - creates watery serous saliva
Sympathetic - norepinepherine - creates thick mucosal saliva

Question 5

What are a few causes of xerostomia?

Answer 5

Medication (some antihistimines), Sjogren’s syndrome,

Question 6

Describe difference between minor and major salivary glands.

Answer 6

Minor - intrinsic - very small amount of saliva directly to the epithelial surface (600-1000 of these)
Major - extrinsic - larger amounts through pathway of ducts

Question 7

Name the 3 major salivary glands

Answer 7

Parotid, Submandibular, and Sublingual

25%, 70%, 5%

Question 8

Difference between sebaceous and serous

Answer 8

Sebaceous refers to glands that secrete mucous

Serous refers to watery secretions

Question 9

What duct empties the parotid gland?

Answer 9

Stenson’s (or Parotid) Duct

25% saliva comes from here

Question 10

What duct empties the submandibular gland?

Answer 10

Wharton’s (or submandibular) duct.

70% Saliva comes from here

Question 11

What duct empties the sublingual gland?

Answer 11

Bartholin’s Duct

5% Saliva from here

Question 12

Describe the Serous/Mucous differences of the major salivary glands.

Answer 12

Parotid Gland is Serous
Submandibular gland is mixed - mostly serous
Sublingual gland is mixed - mostly mucous

Question 13

What is a Sialolith

Answer 13

a salivary stone

Question 14

What type of epithelium is found in intercalated ducts

Answer 14

Simple Cuboidal

Question 15

What are three types of acini?

Answer 15

Serous, Mucous, Mixed (with demilumes)

Question 16

Serous acinus vs. Mucous acinus when stained

Answer 16

Serous vesicles are dark - mucous light

Also - Mucous acinus nucleus and organelles are flattened

Question 17

What’s the function of a myoepithelial cell on the outer surface of an acinus?

Answer 17

Could be a tumor suppressor.

Question 18

What is pellicle formation?

Answer 18

First step toward plaque (“sweaters”)

Question 19

Are serous demilumes crescent in the living cell?

Answer 19

No - shape under slide is due to preparation process. Is an “artifact”

Question 20

What are the 4 major parts of the Salivon?

Answer 20

Acinus, Intercalated duct, Striated duct, Secretory duct.

Question 21

Describe the parotid, submandibular, and sublingual salivary glands in terms of serous/mucous ratios.

Answer 21

Parotid pretty much all serous.
Submandibular Mostly serous. (and produces most saliva)
Sublingual mostly mucous.

Question 22

What does a striated duct resorb?

What does it add?

Answer 22

NaCl
- serves to dilute saliva to mostly water.

IgA (immunoglobulin A) - powerful anti-bacterial/anti-viral

Question 23

What do serous acini look like under microscope and where would you find them?

Answer 23

Pink and dark staining cells with slightly lighter striated ducts

Parotid gland

Question 24

Describe an acinous in the sublingual gland.

Answer 24

Mostly mucous with some serous demilumes

Question 25

Mucous and serous fluid are both released into the lumen and then into ducts

Answer 25

True

Question 26

Histologically describe a slide of an acinus in a submandibular salivary gland.

Answer 26

Mostly dark staining serous cells with some mucous. There should also be round striated ducts.

Question 27

Where is salivary IgA synthesized?

How does it get into the saliva?

Answer 27

By plasma cells in the connective tissue surrounding the acini.

Various mechanisms via the epithelial duct cells (monomer/dimer bonding, endocytosis, exocytosis)

Question 28

What type of cell is an intercalated duct made from?

Answer 28

Simple cuboidal

some secretory components

Question 29

What type of cell makes up the striated duct and what is their function?

Answer 29

Simple columnar with lots of mitochondria close to the basal lamina. Function to remove Na and Cl from saliva making it hypotonic.

Question 30

Where can you find stratified columnar epithelium (a rare type)?

Answer 30

At the effluent end of excretory salivary ducts. The base layer is often more cuboidal, with columnar appearing toward the free surface.

Question 31

What type of membrane does a striated epithelial duct cell have?

Answer 31

Selectively permeable (salts not water).