510-6 Flashcards
mucus
binds to food particles and aids in lubrication and swallowing
salivary amylase
digests starch
lingual lipase
activated by stomach acid once the food is swallowed and it digests fat
histatin
major component in wound repair
SLPI
antimicrobial agent important in HIV defense
IgA
antibody that neutralizes bacteria
lactoferrin
chelates iron so bacteria can’t grow
Parasympathetic Stimulation of Salivary Glands
causes the production of serous, watery saliva
Sympathetic Stimulation of Salivary Glands
produces a small volume of thick mucus saliva
2 main types of salivary glands
minor- located throughout the oral cavity (except gingiva and hard palate)
major- three paired glands stimulated by nerves
mucoceles
blockage of minor mucus gland
3 major salivary glands
- ) parotid
- ) submandibular
- ) sublingual
Parotid
25% of total saliva volume
serous
located in temporal region of head
empties into STENSEN’S DUCT
Submandibular
70% of total saliva
mixed- mostly serous
empties into WHARTON’S DUCT next to the frenulum
Sublingual
5%
mixed- mostly mucus
empties into BARTHOLIN’S DUCT and DUCTS OF RIVINUS
Sialolith
salivary gland stone (most common in Wharton’s Duct)
Sjogren’s Syndrome
Autoimmune disorder where the body destroys its own salivary glands
pellicle
saliva that covers the tooth. important in bacteria defense.
plaque
when the pellicle gets colonized by bacteria
calculus
when the plaque calcifies
3 main bacterial colonizers of dental plaque
- ) s. sanguis
- ) s. mutanns
- ) a. viscosus
2 major types of salivary secretion
- ) serous
2. ) mucus
acinus
cluster of cells arranged in a sphere around a hollow lumen
intercalated duct
joins acinus to striated duct. covered by myoepithelial cells. adds lysozymes and lactoferrin to saliva.
striated duct
adds bicarbonate to saliva and reabsorbs Na and Cl. striated pattern on tall cuboidal cells
serous demilune
during fixation the mucus cells swell leading to serous cells being pushed to the periphery of the acinus
myoepithelial cells
found on secretory acini and intercalated ducts. weakly contractile, similar to muscle cells but derived from epithelia
primary saliva
isotonic
secondary saliva
hyper tonic
Salivary protein secretion
NE binds to B andrenergic receptor which leads to a series of secondary messenger cascades (G protein, AC, cAMP) which eventually leads to the exocytosis of the proteins
Water and Electrolyte Salivary Secretion
Ach binds to muscarinic cholinergic receptor and NE binds to A andrenergic receptor which signals the intracellular release of calcium. this opens Na and Cl channels in the membrane and tight junctions. Aquaporins are also opened which leads to the movement of water.
Secretion of IgA
IgA produced by plasma cells. Epithelia cells produce secretory component that acts as a receptor and binds the IgA and by endocytosis brings it into the epithelial cell and releases it by exocytosis