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Pharm U5 > 5) Transplant - U5 > Flashcards

5) Transplant - U5 Flashcards

1
Q

What is the class for ATGAM; ALG; OKT3

A

Pan T-cell antibodies

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2
Q

What is the mechanism for ATGAM; ALG; OKT3

A

Depletion of T-lymphocytes by inducing complement-mediated cytolysis and cell-mediated opsonization in the spleen and liver

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3
Q

What are the therapeutics for ATGAM; ALG; OKT3

A

Induce immunosuppression to prevent rejection of transplanted organs

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4
Q

What are the important side effects for ATGAM; ALG; OKT3

A

Serum sickness reaction characterized by fevers, chills, tachycardia, hypertension or hypotension, myalgias, and rash

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5
Q

What are the other side effects for ATGAM; ALG; OKT3

A

Pre-disposition to opportunistic infections (long-term)

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6
Q

What is the class for Dacluzimab (Zenapax)

A

IL-2 receptor antibody

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7
Q

What is the mechanism for Dacluzimab (Zenapax)

A

Inhibits IL-2 mediated T-lymphocyte proliferation.

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8
Q

What are the therapeutics for Dacluzimab (Zenapax)

A

Induce immunosuppression to prevent rejection of transplanted organs

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9
Q

What are the important side effects for Dacluzimab (Zenapax)

A

Lower incidence of drug-related adverse reactions than pan T-cell Abs

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10
Q

What are the miscellaneous for Dacluzimab (Zenapax)

A

Discontinued in 2009.

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11
Q

What is the class for Basiliximab (Simulect)

A

IL-2 receptor antibody

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12
Q

What is the mechanism for Basiliximab (Simulect)

A

Inhibits IL-2 mediated T-lymphocyte proliferation.

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13
Q

What are the therapeutics for Basiliximab (Simulect)

A

Induce immunosuppression to prevent rejection of transplanted organs

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14
Q

What are the important side effects for Basiliximab (Simulect)

A

Lower incidence of drug-related adverse reactions than pan T-cell Abs

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15
Q

What is the class for Alemtuzimab (Campath)

A

CD-52 antibody

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16
Q

What is the mechanism for Alemtuzimab (Campath)

A

Supresses both B & T cells to produce a profound lymphopenia

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17
Q

What are the therapeutics for Alemtuzimab (Campath)

A

Induce immunosuppression to prevent rejection of transplanted organs

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18
Q

What is the class for Methylprednisilone

A

Glucocorticoid

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19
Q

What is the mechanism for Methylprednisilone

A

Non-specific anti-inflammatory agent

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20
Q

What are the therapeutics for Methylprednisilone

A

Induce immunosuppression to prevent rejection of transplanted organs; also used for maintenance

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21
Q

What are the important side effects for Methylprednisilone

A

Diabetes mellitus, hyperlipidemia, hypertension, fluid retention, myopathy, osteoporosis, and a predisposition toward opportunistic infections

22
Q

What are the miscellaneous for Methylprednisilone

A

High dose on day1, then rapid daily taper

23
Q

What is the class for Cyclosporin (Sandimmune)

A

Calcineurin inhibitor

24
Q

What is the mechanism for Cyclosporin (Sandimmune)

A

Blocks IL-2 production

25
Q

What are the therapeutics for Cyclosporin (Sandimmune)

A

Used for maintenance of immunosuppression

26
Q

What are the important side effects for Cyclosporin (Sandimmune)

A

Renal insufficiency, hypertension, dyslipidemia, metabolic derangements

27
Q

What are the other side effects for Cyclosporin (Sandimmune)

A

Gingival hyperplasia and hirsutism

28
Q

What are the miscellaneous for Cyclosporin (Sandimmune)

A

Significant drug interactions with any drug metabolized by CYP3A4

29
Q

What is the class for Tacrolimus (Prograf)

A

Calcineurin inhibitor

30
Q

What is the mechanism for Tacrolimus (Prograf)

A

Blocks IL-2 production

31
Q

What are the therapeutics for Tacrolimus (Prograf)

A

Used for maintenance of immunosuppression

32
Q

What are the important side effects for Tacrolimus (Prograf)

A

Renal insufficiency, hypertension, dyslipidemia, metabolic derangements

33
Q

What are the other side effects for Tacrolimus (Prograf)

A

New onset DM; hemolytic-uremic syndrome

34
Q

What are the miscellaneous for Tacrolimus (Prograf)

A

Significant drug interactions with any drug metabolized by CYP3A4

35
Q

What is the class for Azathioprine (Imuran)

A

Antimetabolite

36
Q

What is the mechanism for Azathioprine (Imuran)

A

Inhibits de novo purine synthesis

37
Q

What are the therapeutics for Azathioprine (Imuran)

A

Used for maintenance of immunosuppression

38
Q

What are the important side effects for Azathioprine (Imuran)

A

Leukopenia; hepatotoxicity; pancreatic toxicity

39
Q

What is the class for Mycophenolate (Celicept)

A

Antimetabolite

40
Q

What is the mechanism for Mycophenolate (Celicept)

A

Inhibits de novo purine synthesis

41
Q

What are the therapeutics for Mycophenolate (Celicept)

A

Used for maintenance of immunosuppression

42
Q

What are the important side effects for Mycophenolate (Celicept)

A

Leukopenia (less than azathioprine; GI toxicity

43
Q

What is the class for Sirolimus (Rapamune); Everolimus (Zortress)

A

mTOR inhibitors

44
Q

What is the mechanism for Sirolimus (Rapamune); Everolimus (Zortress)

A

Blocks cell cycle progression from G1 to S phase to inhibit T & B cell proliferation

45
Q

What are the therapeutics for Sirolimus (Rapamune); Everolimus (Zortress)

A

Used for maintenance of immunosuppression

46
Q

What are the important side effects for Sirolimus (Rapamune); Everolimus (Zortress)

A

Hyperlipidemia, oral ulcerations, impaired wound healing, interstitial pneumonitis

47
Q

What is the mechanism for Belatacept

A

Blocks co-stimulation of T cells

48
Q

What are the therapeutics for Belatacept

A

Used for maintenance of immunosuppression

49
Q

What is the class for Rituximab

A

CD-20 mAb

50
Q

What is the mechanism for Rituximab

A

Destruction of B cells

51
Q

What are the therapeutics for Rituximab

A

Combat antibody-mediated rejection after transplatation

Pharm U5 (5 decks)

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