[5] Principles And Concepts Of Pharmacokinetics Flashcards
Systemic Routes of Drug Administration (7)
Oral Sublingual Rectal Cutaneous Inhalation Nasal Parenteral
Factors that Influence Absorption (7)
Physical state Degree of ionization Concentration of drug Circulation to site of absorption Area of absorption Gastric emptying Route of administration Fuck you DJ
Factors that Influence Distribution (4)
Cardiac Output
Vascular Perfusion
Permeability of Tissue Membrane
Relative Partitioning of Drug Between Tissue and Blood
Components of Bound Drug
Free Drug + Protein
Are bound drugs inactive or active?
Inactive, they are like repositories
What is the highest protein binding drug?
Bishydroxycoumarin 99.8%
Formula: Volume of Distribution
Vd: Dose x Availability / Drug Concentration
Bio transformation Differentiate:
Phase I
Phase II
Phase I: Non synthetic
Phase II: Synthetic
Active form of these drugs:
Bacampicillin
Alpha-methyldopa
Enalapril
Ampicillin
Alpha-methyldopa
What is the most important drug metabolizing reaction?
Oxidation Reaction
What cytochrome p450 isozyme metabolizes the largest amount?
CYP3A
Which cytochrome P450 isozyme metabolizes the least?
CYP1A2
2 Types of Drug Metabolizing Enzyme
Microsomal
Non-Microsomal
Differentiate of Microsomal and Non Microsomal Enzymes
Microsomal enzymes can be enhanced by induction, these I’ll not affect non-microsomal enzymes.
Define: Bioavailability
Percentage of drug In a drug product that enters the systemic circulation as a parent compound
