[4] Drug Receptor Interaction

Question 0

What does a drug response scale look like on the negative logarithmic scale?

Answer 0

Sigmoidal

It looks like a straight line and the 50% maximal response level can be easily detected

Question 1

A graded response curve looks like?

Answer 1

Hyperbolic

Question 2

[T/F] Potency of the drug is important

Answer 2

F

It is not as important as compared to the maximal efficacy

Question 3

What is the formula for Therapeutic Index?

Answer 3

LD50/ED50

Question 4

What happens to the curve when you add a competitive antagonist?

Answer 4

The curve gets displaced to the right, requiring more concentration to move it out

Question 5

What happens to the curve when you add a non competitive antagonist?

Answer 5

Adding more of the drug doesn’t make a difference, the entire curve is differ, being lower and less effective than before the addition of the antagonistic substance.

Question 6

Factors that Affect Therapeutic Outcome (6)

Answer 6

Age
Drug drug Interaction
Fixed dose Combination 
Placebo Effects
Tolerance
Genetic Factors

Question 7

Factors that Contribute to Lack of Efficacy (7)

Answer 7

Misdiagnosis
Poor compliance
Poor choice of dosage or dosage intervals
Coincidental development of an undiagnosed separate illness
Concurrent use of other drugs
Undetected genetic or environmental variables that modify the pharmacology of the drug
Unknown therapy by another physician