5 - Introduction to diabetes mellitus Flashcards
How does insulin affect HGO and muscle glucose uptake?
Decreases HGO (hepatic glucose output)
Increases muscle glucose uptake
How does insulin affect proteolysis?
Decreases proteolysis (stops the breakdown of proteins)
How does insulin affect lipids (lipolysis and ketogenesis)?
Decreases both (Ketogenesis is the breakdown of fatty acids and ketogenic amino acids to make ketone bodies)
What are 5 other things insulin is related to?
- Lipoproteins
- Smooth muscle hypertrophy
- Ovarian function
- Clotting
- Energy expenditure
What transporter does glucose enter a cell through?
GLUT4 - insulin increases the amount of these transporters to increase glucose uptake.
Hydrophilic core and hydrophobic edge.
Where is GLUT4 found?
Muscle and adipose tissue
In a muscle cell, how does insulin affect proteins?
Stops proteolysis (stops the breakdown of proteins)
Increases protein synthesis (also increased by growth hormone)
What increases proteolysis in muscle cells and what are the amino acids used for?
Cortisol
Used to make O2 into CO2
Used to make gluconeogenic amino acids.
What is the difference between where glucose and glycogen are stored?
Glucose is always present in the blood
Glycogen is stored in the liver
What happens to gluconeogenic amino acids that enter the liver?
- Used to make proteins
- Used to make new glucose (gluconeogenesis) to increase HGO
In the blood vessels and in adipose tissues, insulin has different effects on the formation and breakdown of triglycerides. Explain this.
In blood vessels, insulin encourages the breakdown of triglycerides.
Its broken down into non-esterified fatty acids and glycerol which can enter adipose tissue.
In adipose tissue, insulin encourages the formation of triglycerides. This can be from NEFAs and glycerol-3-p.
What 3 things encourage the breakdown of triglycerides in adipose cells into NEFAs?
Cats
Cort
GH
What is the omental or hepatic portal circulation?
Blood goes to the gut, picks up nutrients.
This blood goes to the liver so food can be processed BEFORE re-entering general circulation.
Adipocytes in central circulation are different to those in arms and legs. Omental adipocytes predict heart disease.
How is glycerol used to make glucose in the liver? Draw diagram
Triangle.
Glycerol enters and is made into Glycerol-3-p.
This can be made (reversibly) into triglycerides.
Glycerol-3-p makes glucose via gluconeogenesis. This is released from the liver.
What CANNOT be used to make glucose
Non-esterified fatty acids