5. Critical Care Flashcards
essence of critical care
correcting the imbalance of disordered perfusion
shock
abnormality of circulatory system that causes inadequate organ perfusion and tissue oxygenation
hypodynamic shock
low cardiac index
vasoconstriction
inadequate BF
hyperdynamic shock
high cardia index
vasodilation
maldistribution of blood
types of hypodynamic shock
hypovolemic
cardiogenic
obstructive
hypovolemic shock
decr cardiac filling pressures
causes of hypovolemic shock
hemorrhage
dehydration
massive capillary leak
cardiogenic shock
normal cardiac filling pressures
most common cause of cardiogenic shock
acute MI involving 40% L ventricular mass
other causes of cardiogenic shock
cardiomyopathies
valvular lesions
obstructive shock
incr cardiac filling pressures
what causes change to cardiac filling pressure in obstructive shock?
incr cardiac filling pressures due to:
- outflow obstruction
- decr ventricular compliance
causes of obstructive shock
pericardial tamponade
acute pulm embolism
tension pneumothorax
type of hyperdynamic shock
septic
traumatic
septic shock
direct mediators of inflammation and tissue hyperperfusion result in cellular injury/organ dysfunction
traumatic shock
inflammatory mechanism
distributive immunologically mediated response to injury
traumatic shock results from
hemorrhage
what do sepsis and severe trauma have in common?
systemic inflammation
if you have a localized infection/trauma is the response localized or systemic?
typically localized
sepsis
life-threatening
organ dysfunction causes by dysregulated host response to infection
what type of dysfunction is sepsis?
circulatory
cellular/metabolic
sepsis hypoperfusion resuscitation
30 ml/kg over 3 hours
additional sepsis resuscitation is guided by
reassessment of vitals
with sepsis you need to ______ to guide treatment
diagnose the source of the sepsis to guide abx therapy
sepsis infection treatment
empirical broad-spectrum abx
within 1 hr of diagnosis
how often should you reasses abx choice in sepsis
1x daily
sepsis treatment is focused on
source control
(origin of infection)
when should you continue volume resuscitation in sepsis pts?
if the pt is responsive
what fluids should you not give sepsis pts
HES can cause renal injury
black box warning
what fluid do you want to give sepsis pts?
albumin to incr oncotic pressure
MAP goal in sepsis
65
vasopressor priority for sepsis pts
1: NE (beta/alpha)
2: epi (alpha/beta)
3: vasopressin
which drug to avoid in sepsis
dopamine causes arrythmias
inotrope of choice in sepsis
dobutamine
steroids _____ immune response
decr immune response
should you give steroids to sepsis pts who are stable?
NO
should you give steroids to sepsis pts who are unstable?
maybe - decr immune response may help curb sepsis symptoms
hb target for transfusion
7-10 g/dL
ventilator goals in sepsis-ARDS
normal CO2
SpO2 > 93%
sepsis-ARDS TV
4-6 mL/kg
sepsis-ARD RR
incr
sepsis-ARDS PEEP
increased
CVVH
continuous renal replacement therapy
(continuous dialysis commonly used in ICU)
CVVH rate
slower rate of solute and fluid removal
sepsis blood glu goal
Glu < 180 mg/dL
systemic inflammatory response syndrome (SIRS)
- acute proinflammatory response mediated by incr in innate immune gene expression (SIRS)
- anti-inflammatory response that modulate proinflammatory response (CARS)
proinflammatory response
cytokines
SIRS diagnosis
2+:
temp > 36-38C
HR > 90 bpm
RR > 20
PCO2 < 32 mmHg
WBC > 12 or < 4
SIRS pts ventialtion
hyperventilation
- respiratory compensation for metabolic process
how many stages of SIRS
5 (SIRS -> MODS)
MODS
multiorgan dysfucntion syndrome
Compensatory anti-inflammatory response syndrome (CARS)
body tries to regain immunological balance but overcompensates