1. Peds Flashcards
full term
37-41 weeks gestational age
preterm
< 37 weeks
Small for gestational age
birth weight < 10th %
Large for gestational age
birth weight > 10th %
embryonic lung development
4-7 weeks gestation
psuedoglandular lung development
5-17 wks gestation
canalicular lung development
16-26 wks gestation
saccular lung development
24 wks to birth
alveolar lung development occurs
after birth to 3 years
when does the bronchial tree develop?
pseudoglandular stage
when does the differentiation of type 1 and type 2 surfactant occur?
canalicular stage
when is surfactant mature?
saccular stage
how many alveoli at birth?
30-50 million
amniotic fluid function
protects baby
fetal breath movements (FBM)
pulls fluids into lungs
opens alveoli
stimulates growth
amniotic fluid contains
urine and lung secretions
fetal blood from IVC flows
through foramen ovale
fetal blood from SVC flows
through trucsupid
fetal lungs PVR
higher due to HPV
fetal circulation is _____ while adult circulation is ______
fetal circulation is 2 parallel circuits while adult circulation is 1 circuit in series
umbilical arteries carry
deoxy blood
umbilical vein carry
oxy blood
umbilical vein PO2
55 mmHg
fetal hb subunits
2 alpha
2 delta
fetal hb p50
19 mmHg
fetal hb-o2 shift
Left Shift
what happens to BF through PDA at birth
decr SVR causes BF to bypass PDA
what closes PFO
incr pulm circulation
incr LA P
how do you avoid baby hypoxia at birth
delayed cord clamping
infant ribs/diaphragm
parallel ribs
flatter diaphragm
compensate by incr RR
infants response to CO2
decr ventilatory response
infants response to hypoxic mixture
incr ventilation for 1 min
5 min hyponea
infants response to hypoxic mixture due to
immature carotid bodies
infant respiratory diffferences
decr TLC
decr TV
decr FRC
incr O2 consumption
incr MV
incr closing capacity (incr atelectasis risk)
infant diaphragm compostion
25% type 1 aerobic muscle fibers means they need mechanical ventilation help bc tire easily
infant airway differences
larger tongue
cephalad larynx
narrow omega epiglottis
angled vocal cords
narrowest part of infant airway
cricoid cartilage
level of glottic opening: preterm infant
C3
level of glottic opening: fulterm infant
C3-C4
level of glottic opening: adult
C4-C5
pediatric SV
fixed due to non-compliant LV
pediatric CO
HR-dependent
are peds pts parasympathetic or sympathetic dominant?
parasympathetic
peds renal drug elimination
decr renal drug elimination
incr DOA
peds urine
dilute
Cr at birth
same as mother
Cr 48 hrs post-birth
0.5 mg/dL
[Hg] at birth
19 g/dL
HgF at birth
70%
why is peds Hg so high?
incr EPO
cranial sutures
elastic tissue bands
- fontanels at junction of cranial sutures
anterior fontanel closes
20 months
posterior fontanel closes
3 months
which drug is neuroprotective
dexmedetomidine
which drugs do not cause neuroapoptosis
narcots
PANDA study
no sig difference in IQ when exposed to anesthetics
GAS study
no diff in neurodevelopment at 5 yrs
Mask Study
no statistica difference between kids w or w/o anesthetic exposures
risk of anesthesia in peds incr with
longer duration
increased frequency
peds drugs with hepatic metabolism
longer DOA
fentayl metabolism by newborn
50%
full-term neonate glycogen
similar to adults
peds oral midazolam dosing
0.3-0.7 mg/kg
oral midazolam onset
10 mins
peds precedex doing
2 mcg/kg