5 Antibodies-classes And Immunity Flashcards
What chains of immunoglobulin determine the class/type of an antibody?
What chains are shared by all classes?
Heavy chains determine isotype! Unique to each class
Light chains (kappa or lambda) are shared by all classes
What class of antibodies are most common?
Which cross the placenta?
Which predominates in secondary immune response?
Which predominates in primary immune response?
IgG
IgG
IgG
IgM
In the _______ response there’s a long lag between stimulus and antibody. 3-4 days with pathogens and 10-14 with killed bacteria. HIV 2-_ weeks.
It’s primarily Ig_ which is synthesized first. This is your primary vaccination.
The secondary response is _____ and primarily Ig_. This is often used as your booster vaccination and so you have MUCH _____ of this compared to what’s in your primary.
Primary. 2-6 weeks.
IgM!
FAST. IgG!
More
Identify whether the
form of immunity is active natural, active artificial, passive natural,
or passive artificial.
Vaccines? (Immune globulin, antivenom)
Natural Infection?
Immunization with altered agent or antigens?
Mother-child (IgG-placenta, IgA-breast milk)
Immunization with antibodies?
Passive artificial
Active natural
Active artificial
Passive natural
Passive artificial
The major antibody classes are determined by the amino acid sequence of which one of these??
Heavy chains
Light chains
Fc region
Fab region
HEAVY CHAINS
Post-Rabies Prophylaxis? What would you do administer to somebody who just got rabies?
RIG + Antigen
A person was exposed to Hep B virus and got vaccination with Hep B surface antigen + dose of Hep B immunoglobulin.. what types of immunity confirmed?
- Active artificial
- Active natural
- Passive artificial
- Passive natural
BOTH active and passive. Both are artificial as well!
So 1 and 3
Which antibody can fix complement?
Which one is involved in allergic responses and parasitic infections?
Which binds to APCs and PMNs?
Which binds to basophils/mast cells?
IgG
IgE
IgG
IgE
