4.Pediatric Flashcards
Nephrotic vs Nephritic syndromes ??
Catch up schedule for varicella vaccine:
● Less than 7 year old; 2 doses with 3 months apart
●More than 7 year old; 2 doses with 1 month apart **MCQ
Case of child with meningitis, what you will give for close contact ( his brother & sister ) as prophylaxis?
Ciprofloxacin one dose
Note :
- Rifampicin - 4 doses orally
Or
- Ciprofloxacin- Single oral dose
Or
- Ceftriaxone - Single IM dose
UpToDate
Types of vaccines…
Killed»_space;
(I Killed A Dragon By my High Power)
I = IPV
A = hepatitis A
D = DTaP
B = hepatitis B
H = Hib
P = PCV
LIVE ATTENUATED (I live in a Very Big ROOM)
V= Varicella
B= BCG
R= Rota
O= OPV
M= MUMPS,MEASLES, RUBELLA (MMR)
Note; yellow fever & influenza are live attenuated vaccines
How to give hepatitis B vaccine ?
Intramuscular
Note :
Route of Administration:
• Live vaccines: Subcutanous
• Killed vaccines: Intramusular
• BCG: Intradermal
• Oral: polio, rota
By Dr.Safedr
Vaccine for 9 months old
• A-DTaP , HiB , Oral polio
• B-Meniniogococcus , measles
• C-MMR , Meningiococcus
• D-Pneucoccal , Hepatits B
Answer is : C
See below when to give vaccines
Mother is hepatitis B positive • Baby weight is 1.6 kg
• A-Give Hep B vaccine
• B-Wait till weight reached 2 kg and then give vaccine
• c-Check the hepatitis B status for the baby
• D-Give both Hep vaccine and hepatitis B
immunoglobulin
Answer is D
If mother HB –ve; Wait until; Baby be 1 month Or Baby reach 2 kg or at time of discharge
●If mother HB +ve; Give HBV vaccine and HBV Ig (Regardless of the weight)
optimal time to give PCV vaccines after
Spleenoectomy..
• A- 2 weeks
Note ; vaccination against encapsulated bacterial
like pneumococcal or meningococcal should be given
2 weeks at least before splenectomy or 2 weeks after splenectomy
By Dr.Safder
Which vaccines are absolute contraindicated in pt with HIV ?
OPV and BCG
And lived attenuated vaccines are contraindicated in immunocompromised patients
Duration of Dtap vaccine is
10 years
Absolute contraindications for DTP vaccine ..
Progressive encephalopathy within 7 days from
previous DTP vaccines
Specific Contraindications for vaccines
●Contraindicated in Intussusception; Rota
●Contraindicated in egg allergy; yellow fever
●Contraindicated in gelatin and neomycin allergy; varicella and MMR ●Contraindicated in lactating mother; small pox and yellow fever
●DTP Contraindications: 3 D’s; Developmental delay, Dysmorphic features, Neurological system Disorder (encephalopathy within 7 days or uncontrolled seizure)
Immunodeficiency:
□SCID (bacteria, viral and fungal infections), All vaccine are contraindicated
□ X linked aggamaglublmemua; only live vaccines are contraindicated
□Chronic granulomatosis disease; only live bacterial vaccine is contraindicated (BCG, Typhoid, plague)
□IgA deficiency; most common, Protozoal infections and chronic diarrhea from giardiasis; can receive all types of vaccine
□Complement deficiency; can receive all types of vaccine
Regarding contraindicated vaccine in HIV patient:
●if CD4 more than 200; Only OPV, BCG vaccines are contraindicated
●if CD4 less than 200 (AIDS); All live attenuated vaccines are contraindicated
Varicella vaccine is given
2 doses within 3 months apart
Remember:
Live vaccine: If not given at the same time → You should wait 4 weeks to give another live vaccine
— Minimal interval between same vaccine is 4 weeks Except;
●Hepatitis A: 6 months
●Meningiococcus: 8 weeks
●Varicella vaccine: 3 months
In Sickle cell diseae, splenectomy, nephrotic syndrome, you give
Pneumococcal vaccine,
Menegiococcal vaccine, HiB
Catch up schedule for varicella vaccine:
In children less that 13years: 2 doses with 3 months
apart •
In children above13 years: 2 doses with 4 weeks
apart
By Dr.Safder
Contraindications for yellow fever vaccine
Allergy to • Egg • Chicken protein • Gelatin
contraindication for
varicella vaccines
Allergy to neomycin or gelatin are contraindications to
MMR and varicella
One month boy came for vaccine. His older
sister (6 years old) had renal transplant and now
is on immunosuppressive medication. Which
vaccine is contraindicated for the boy?
OPV ( oral polio )
●OPV should not be given if there is a family member with immunocompromised conditions (can be disseminated by fecal-oral route to other individual)
any immunosuppressed patients with a contact
with chicken pox should
receive varicella zoster
immunoglobulin
Patient is known nephrotic and he finished steroid
just now and wants MMR vaccine
Ask her to come back after 4 weeks
Remember:
Live vaccine after stopping;
●Steroid, MMF, cyclosporine; 4 weeks
●Chemotherapy, cyclophosphamide; 3 months
●Bood transfusion; 6 months
●IVIG; 11 months
Live Vaccine should be delayed (especially MMR or
varicella)
3-11 month after IVIG
• 6 months after PRBC
• 7 months after FFP or platelets
• Immediately after packer RBC blood products
Note : Recent blood transfusion is not a reason to delay
killed vaccine like hepatitis A.
Patient with chronic respiratory disorder should
receive
Influenza • Pneumococcal
Catch up vaccine for 6 years old that didn’t receive any vaccination ..
DTP , varicella , MMR , pneumococcal, IPV , hepatitis B , HIB
EXCEPT ROTA !!
Catch up vaccines • For all children below 7 years • Need catch up all vaccine except rota vaccine if he is
above 8 months • Need to catch up for all bacterial vaccine
For children above 7 years will need catch up for all
viral vaccine except Rota • No need for bacterial vaccines except DT • Nesseria and pneumococcal only in high-risk patients
(SCA and nephrotic syndrome)
By Dr,Safder
• A mother is unvaccinated, and she is concerned
about tetanus neonatorum
Give mother DtAp at 28 weeks of geastion
By Dr,Safder ;
CDC recommends that pregnant women should
receive a single dose of DTaP between 27 to 36
weeks • It can 2 weeks for babies to develop antibodies if
mother vaccinated during pregnancy
The best way to decrease asthma exacerbation is
Receive influenzas virus vaccines
When to give live vaccines in pt on chemotherapy ?
given wither 2 weeks
before starting chemotherapy or after 3 months from
stopping chemotherapy
Indications of influenza vaccine ?
• Pregnant woman
• Immunodeficiency
• Children on aspirin
• Children below 5 years
• Resident of healthcare facilities
Regarding live vaccine in pregnant taking anti-TNF;
- In 2nd trimester; delay 6 months
●In 3rd trimester; delay 12 months
Most common cause of infective endocarditis in children in general is …
Answer is ; staph aureus»_space; normal heart
Streptococcus virdans»_space; patients with underlying congenital heart disease or valve disease
Staph epidermis» patient with prosthetic heart valve , 12 months post insertion, Staph aureus more than 12 months post insertion.
By Dr,Safder
Best empirical regimen for child with infective endocarditis & prosthetic valve is ..
Vancomycin to cover MRSA
Or
gentamycin and rifampicin or cefipime .
Child with infective endocarditis in native valve what is empirical antibiotic..
vancomycin
Most important investigation in case of child with infective endocarditis is
Blood culture
Diagnosed by blood culture (should be repeated 3 times and best timing for culture during fever)
Diagnosis is of infective endocarditis is ..
By Modified Duke Clinical criteria
• 2 major
• Or
• 1 major and 3 minor
• Or
• 5 minor
Endocarditis prophylaxis in :
• before dental procedure
المزرق Unrepaired Cyanotic congenital heart disease e,g. TOF •
صاحب التاریخ المسبق Previous history of infective endocarditits •
المصطنع With prosthesis except for peacmaker •
• After heart surgery if there is:
• 1- prosthesis (except pace maker)
• 2- residual VSD or ASD
• 3-Shunt
المرتجع( Cardiac transplant surgery with valve regurgitation •
• Respiratory procedures
• Procedures in infected skin , soft tissues or musculoskeletal system
• GIT or genitourinary procedures if there onging infection olny
How to prevent IE ?
Amoxicillin or Ampicillin
procedure my cause bacteremia:
-dental or tonsillectomy (mouth) -surgery involving respiratory system. -SKIN procedures
-I&D of infected tissue.
What are indications of cardiac surgery in case of ( infective endocarditis) IE ?
In patients with
• Fungal endocarditrs
• Severe valve regurgitation
• Dehiscence of prosthesis valve
• Myocardial abscess
• Mycotic anuresym
By Dr.Safder
See below by Rayan