4b (diversity, selection and classification) Flashcards
what is diploid?
what is haploid?
2n chromosomes- 2 of each chromosome one from each parent
n number of chromosomes- one of each
what does fertilisation is random mean? what does it result in?
any sperm can fertilise any egg
results in zygotes w diff combo of chromosomes to both parents
what happens in meiosis?
interphase- DNA replication
Meiosis 1- homologous chromosomes separated from each other
meiosis 2- sister chromatids become separated
4 genetically different haploid cells are produced
what happens in meiosis 1?
prophase 1- nuclear envelope breaks down, spindle fibres form from centrioles, homologous chromosomes wrap around each other, crossing over occurs leading to variation
metaphase 1- chromosomes line up next to homologous partner at equator, centromeres attach to spindle fibres, chromosomes randomly organised on either side of equator- independent assortment leads to variation
anaphase 1- separation of homologous chromosomes to opposite poles, one of each pair will end up on either side so variation
telophase 1- reforming of the nuclear envelope
cytokinesis- cytoplasm splits
what happens in crossing over?
homologous chromosomes associate
chiasmata form
equal lengths of non-sister chromatids/ alleles are exchanged
producing new combinations of alleles
what happens in meiosis 2?
prophase 2- dna becomes condensed and visible again, nuclear membrane disintegrates, spindle fibres form, chromosomes are not identical
metaphase 2- chromosomes line up at centre attached by spindle fibres, randomly assorted to either side so variation
anaphase 2- genetically diff chromatids randomly segregated to opposite poles by spindle fibres contracting
telophase 2- nuclei reform
cytokinesis- cell splits, 4 cells, haploid
how does crossing over lead to variation?
in meiosis 1, homologous chromosomes pair up
chromatids twist around each other and bits of chromatids swap over
chromatids still contain same genes but diff combos of alleles
how does independent segregation lead to variation?
each homologous pair has 1 maternal and 1 paternal
when separated in meiosis1, chromosomes end up randomly in daughter cells
so 4 daughter cells have completely diff combos of maternal and paternal chromosomes
different outcome of meiosis/ mitosis
meiosis:
produces cells with half no of chromosomes as parent
daughter cells genetically diff from each other and parent
4 daughter cells
mitosis:
produces cells with same no of chromosomes as parent
daughter cells genetically identical to each other and parent
2 daughter cells
why are mules infertile?
metaphase 1, homologous chromosomes associate w each other to form bivalents but this can only happen if homologous chromosomes are similar size etc
donkey and horse chromosomes too diff to line up
also odd no so one is left unpaired
mitosis can still occur though as pairing up of homologous chromosomes is only in meiosis
what is a chromosome mutation?
variations in number of whole chromosomes or parts of chromosomes
caused by errors in meiosis
lead to inherited conditions as the errors are in gametes
example of chromosome mutation
non-disjunction
leads to down’s syndrome
chromosome 21 fails to separate properly in meiosis so one cell gets extra copy and one gets none
when this gamete fuses with another, results in 3 copies of chromosome 21
what is a mutation?
change in DNA base sequence
means amino acid sequence and protein are altered
(diff amino acid coded for so diff protein)
what is a mutagen?
eg
physical/ chemical agent that changes genetic material and increases frequency of mutations above normal background level
ionising radiation (gamma)
uv
nitrosamines in tobacco
viruses
mustard gas
benzene- industrial solvent
what is a substitution?
a single nucleotide base is replaced by another
what is a silent mutation?
no change to the primary structure of the polypeptide despite having change in base
due to degenerate nature of dna- substitution may still code for same amino acid
what is a deletion?
what effect does it have?
one base is deleted
knock on effect of all triplet codes
reading frame splits sequence into non-overlapping sections but deletion causes frame shift so every amino acid downstream of the mutation is effected.
what has happened if the chromosome number has halved?
meiosis
what has happened if the chromosome number has doubled?
fertilisation
what has happened if the chromosome number stays the same?
mitosis
what is non-disjunction?
the chromosomes fail to separate properly
what is aneuploidy?
the presence of an abnormal number of chromosomes in a cell eg having 45 or 47 chromosomes when 46 is expected in a human cell
What 4 things lead to variation?
2n possible combinations of maternal and paternal chromosomes
crossing over in meiosis 1
independent segregation in meiosis
random fusion of haploid gametes at fertilisation
what is genetic diversity?
number of different alleles of genes in a species or population
what is a population?
a group of organisms of one species living in a particular habitat