4B - Diversity, Classification And Variation Flashcards
What are gametes?
- Sex cells with a haploid number of chromosomes (n)
* Sperm cells in makes and egg cells in females
What is fertilisation?
When a haploid sperm and haploid egg fuse to give a zygote with a diploid number of chromosomes.
What does haploid mean?
Having only one chromosome from each pair.
What does diploid mean?
Having two of each chromosome.
What is the symbol for haploid?
n
What is the symbol for diploid?
2n
What is formed when two gametes join?
Zygote
Are gametes haploid or diploid?
Haploid (n)
Are normal body cells haploid or diploid?
Diploid (2n)
In a normal body cell, where does each of the two chromosomes in a pair come from?
One from the mother and one from the father.
How does fertilisation produce genetic diversity?
- Any sperm can fertilise any egg
* So random fertilisation can produce zygotes with different combinations of chromosomes to both parents.
How is fertilisation random?
Any sperm can fertilise any egg.
How are gametes formed?
By meiosis.
Where does meiosis take place?
In the reproductive organs.
What are chromatids?
- Identical copies of a chromosome made by semi-conservative replication.
- i.e. In a double-armed chromosome, each arm is called a chromatid.
What is a centromere?
The point where the chromatids are joined in a double-armed chromosome.
Describe the process of meiosis.
1) Before meiosis, DNA unravels and replicates so there are two copies of each chromosome, called chromatids (i.e. 2 copies of mother’s chromatid 1 and 2 copies of father’s chromatid 1)
2) DNA condense to form double-armed chromosomes made from two sister chromatids and joined by a centromere.
MEIOSIS I
3) Chromosomes arrange themselves into homologous pairs (two double-armed chromosomes make up a homologous pair)
4) Chromatids twist around and sections of the chromosomes swap over -> Have the same genes, but different alleles.
5) The homologous pairs are separated randomly, so that it is random which chromosome from each pair ends up in which daughter cell.
MEIOSIS II
6) Pairs of sister chromatids in each chromosome are separated -> Centromere is divided.
7) Four haploid cells (gametes) that are genetically different are produced.
Describe the chromosome number before meiosis.
2n
Describe the chromosome number after DNA is replicated before meiosis I.
2 x 2n
Describe the chromosome number after meiosis I.
2 x n
Describe the chromosome number after meiosis II.
n
What are autosomes?
Chromosomes other than sex ones.
What are homologous chromosomes?
- Corresponding chromosomes from a pair, one from the father and one from the mother.
- Of the same size and with the same genes.
- e.g. Chromosome 1 from your mother and chromosome 1 from your father.
Remember to practise writing and drawing out the process of meiosis.
Pg 88 of revision guide.
How does the definition of chromosome change throughout meiosis?
- When a chromosome is on its own, it is called a chromosome
- Where there is a double-armed X structure, the whole thing is called a chromosome, while each branch is called a chromatid
When asked to spot when meiosis happens in an organism, what must you do?
Remember that meiosis is needed to produce gametes with half the number of chromosomes as the parent cell
When in meiosis is chromosome number halved?
- During meiosis I.
- NOT during meiosis II, because the number of chromosomes stays the same -> They just become single-armed instead of double-armed (even though genetic material is halving).
What are the two ways in which meiosis produces genetic diversity?
1) Crossing over of chromatids in meiosis I
2) Independent segregation of chromosomes in meiosis I
Describe the crossing over of chromatids in meiosis I.
- Homologous pairs of chromosomes come together and pair up
- Chromatids twist around each other and parts of chromatids swap over
- Chromatids still contain the same genes, but now have a different combination of alleles
Describe how crossing over of chromatids in meiosis I produces genetic diversity.
Each of the four daughters cells formed from meiosis contains chromatids with different alleles.
Remember to practise drawing out the process of crossing over of chromatids in meiosis I.
Pg 89 of revision guide
What is the name for the random sorting of chromosomes into daughter cells in meiosis I?
Independent segregation
Describe independent segregation of chromosomes in meiosis I.
- Each homologous pair of chromosomes in your cells is made of one chromosome from your mum and one from you dad
- When these are separated in meiosis I, it’s random which chromosome from each pair ends up in which daughter cell
- This is called independent segregation
Describe how independent segregation of chromosomes in meiosis I produces variation.
- Each homologous pair of chromosomes in your cells is made of one chromosome from your mum and one from you dad
- When these are separated in meiosis I, it’s random which chromosome from each pair ends up in which daughter cell
- So the four daughter cells produced have completely different combinations of those maternal and paternal chromosomes.
Remember to practise drawing out the process of independent segregation in meiosis I.
Pg 89 of revision guide.
Give all of the sources of genetic variation in reproduction.
- Meiosis I -> Crossing over between chromatids
- Meiosis I -> Independent segregation
- Random fertilisation
Compare the cells produced by meiosis and mitosis.
MITOSIS
• Same number of chromosomes as the parent cell
• Generically identical to each other and parent cell
• Two daughter cells
MEIOSIS
• Half the number of chromosomes as the parent cell
• Generically different from one another and the parent cell
• Four daughter cells
Explain why meiosis and mitosis have different outcomes.
- Mitosis has one division, while meiosis has two -> Mitosis produces 2 cells with the same number of chromosomes as the parent cell, while meiosis produces 4 cells with half
- Meiosis involves crossing over of chromatids and independent segregation, while mitosis doesn’t -> Mitosis produces genetically identical cells, while meiosis produces genetic variation
What is a chromosome mutation?
- When there is an error in meiosis so that the cells produced contain variations in the numbers of whole chromosomes or parts of chromosomes.
- e.g. Having a 3rd chromosome in a certain pair.
What causes chromosome mutation?
Errors in meiosis
Why do chromosome mutations lead to inherited conditions?
The errors are present in the gametes.
Describe what causes Down’s Syndrome.
1) Caused by a person having an extra copy of chromosome 21 (or part of it).
2) Non-disjunction occurs in meiosis I -> One cell gets an extra copy of 21 and another gets none.
3) When the gametes fuse at fertilisation, the resulting zygote will have three copies of chromosome 21.
What is the name for the failure of chromosomes to separate properly in meiosis I?
Non-disjunction
In which part of meiosis can non-disjunction occur?
Meiosis I
Down’s Syndrome is caused by having an extra chromosome…
21
Remember to practise drawing out how Down’s Syndrome can occur.
Pg 90 of revision guide.
What is a gene mutation?
A change in the base sequence of DNA.
What is the difference between chromosome mutation and gene mutation?
- Chromosome mutation -> When cells produced contain variations in the numbers of whole chromosomes or parts of chromosomes.
- Gene mutation -> When there is a change in the DNA base sequence of chromosomes.
What are the two main types of gene mutation?
- Substitution
* Deletion
What is substitution?
- When one base is substituted with another.
* e.g. ATGCCT becomes ATTCCT
What is deletion?
- When one base is deleted, shifting the rest of the code to the left.
- e.g. ATGCCT becomes ATCCT
Aside from substitution and deletion, what are some other types of mutations?
- Insertion
- Duplication
- Addition
- Translocation
Why effect might a gene mutation have and why?
- The order of DNA bases determines the order of amino acids in a particular protein.
- If a mutation occurs, the sequence of amino acids or codes for (and the protein formed) could be altered.
Why might not all gene mutations affect the order of amino acids in the resulting polypeptide?
- Genetic code is degenerate -> Some amino acids are coded for by more than one triplet
- Some substitutions might change a triplet in such a way that the same amino acid is added to the polypeptide
Which gene mutations are likely to affect the order of amino acids?
- Substitution -> Sometimes lead to a change in the amino acid sequence
- Deletion -> Always lead to a change in the amino acid sequence, due to frame shift
What happens when deletion occurs in a gene?
- The bases to the right of the deletion will shift to the left -> Frame shift
- This means that different amino acids are added to the polypeptide
- A completely different protein is produced
When do gene mutations occur?
Spontaneously -> e.g. when DNA is misread during replication.
Compare when chromosome mutations and gene mutations are likely to happen.
- Chromosome mutations -> During meiosis
* Gene mutations -> During DNA replication
What is frame shift?
When a base is deleted and all of the bases to the right of it shift to the left.
What can increase the rate of gene mutation?
Mutagenic agents
Give some examples of mutagenic agents.
- UV radiation
- Ionising radiation
- Some chemicals
- Some viruses
What is a population?
A group of organisms of a one species living in a particular habitat.
What is genetic diversity?
The number of different alleles of genes in a species or population.
What is a gene pool?
The total number of alleles in a given population at the time.
What is allele frequency?
The number of times an allele appears in the population for a specific gene.
What is reproductive success?
How successful an individual is at breeding and producing offspring.
What things can increase genetic diversity in a population?
- Mutations in the DNA -> Forming new alleles
* Different alleles being introduced into a population by a migrating individual
What is gene flow?
When different alleles are introduced into a population by individuals that migrate into them and reproduce.
What is genetic diversity responsible for?
Natural selection
What is a genetic bottleneck?
- An event that causes a big reduction in a population
* e.g. when a large number of organisms within a population die before reproducing
What is the effect of a genetic bottleneck?
- There is a large reduction in a population.
- Reduced number of different alleles in the gene pool.
- This reduces the genetic diversity.
- The survivors reproduce and a larger population is created with less genetic diversity.
Give an example of a genetic bottleneck and its effect.
- Northern elephant seals were hunted by humans in the late 1800s.
- Original population was reduced to about 50 seals.
- Since then, these seals have produced a population of about 170,000.
- But this population has very little genetic diversity compared to southern elephant seals, who never suffered this.
What is the founder effect?
- When just a few organisms from a population start a new colony and there are only a small number of different alleles in the initial gene pool.
- It is a type of genetic bottleneck.
What effect might the founder effect have on genetic diseases and why?
- There may be a higher incidence of certain genetic diseases.
- Because the frequency of each allele in the new colony might be different from the original population.
- An allele that was rare in the original population might be more common in the new colony.
Give an example of a type of genetic bottleneck.
The founder effect.
Why might the founder effect occur?
- Migration leading to geographical separation
* Separation of a colony for another reason, e.g. religion
Give an example of the founder effect and its effects.
- Amish population of North America are all descended from a small number of Swiss who migrated there.
- The population shows little genetic diversity.
- They have remained isolated due to their religious beliefs, so no new alleles have been introduced.
- Population has an unusually high incidence of certain genetic disorders.
Are mutations good or bad? Why?
- They can result in a new allele
- This allele can be harmful -> So it does out quickly
- This allele can be beneficial -> Natural selection helps the frequency of that allele in a population increase
How can you work out he number of possible chromosome combinations following meiosis and then fertilisation?
- After meiosis = 2^n
- After fertilisation = (2^n)²
Where n = number of pairs of homologous chromosomes.
Calculate the number of possible chromosome combination produced from the fertilisation of two gametes from separate individuals whose diploid number is 12.
- n = 12 / 2 = 6
* (2^n)² = (2^6)² = 4096
Are all individuals in a population equally likely to reproduce?
- No, there is differential reproductive success.
* Individuals with beneficial alleles are more likely to survive and reproduce.
Describe how natural selection can happen.
1) Variation in phenotype due to variation in alleles via mutation.
2) So there is a differential reproductive success.
3) There is selective pressure, such as a predator.
4) Individuals with a beneficial allele are more likely to survive, reproduce and pass on the beneficial allele.
5) So a greater proportion of the next generation inherits the beneficial gene -> This repeats.
6) The frequency of the beneficial allele increases through generations.
7) Over time, this leads to evolution.
What is evolution?
The gradual change in species over time.
What are two keys factors in evolution?
- Adaptation
* Selection
What do adaptations do?
Help organisms survive in their environment.
What are the 3 types of adaptation?
1) Behavioural adaptations
2) Physiological adaptations
3) Structural adaptations
What are behavioural adaptations?
Ways an organism acts that increase its chance of survival and reproduction.
Give an example of a behavioural adaptation.
Possums may “play dead” if they’re being threatened by a predator to escape attack.
What are physiological adaptions?
Processes inside an organism’s body that increase its chance of survival.
Give an example of a physiological adaptation.
Brown bears hibernate over winter -> Lower their rate of metabolism, which conserved energy.
What are structural adaptations?
Physical features of an organism’s body that increase its chance of survival.
What is another name for structural adaptations?
Anatomical adaptations
Give an example of a structural adaptation.
Whales have a thick layer of blubber, which helps them keep warm in the cold sea.
What are the two types of natural selection?
- Stabilising selection
* Directional selection
What is directional selection?
- Where individuals with alleles for characteristics of an extreme type are more likely to survive and reproduce.
- This causes the mode to shift to the extreme.
Give an example of directional selection.
- Antibiotic resistance
- When bacteria are exposed to an antibiotic, the ones with the allele that gives them resistance are more likely to survive and reproduce, passing on the allele.
- The mode shifts towards high antibiotic resistance.