4.2 Flashcards
Replicative Cycle
Attachment
actual binding of spike proteins on the virus to the host cell receptors (grabbing door handle of classroom)
Penetration
Viral Entry (opening the door)
occur by breaking through the membrane, endocytosis, or membrane fusion
*Some viruses puncture through host membrane w/ injectosome (like T6SS)
Uncoating
capsid breaks open and the viral genomic material is released (unpacked, taken off jacket)
Synthesis
the actual creation of viral genomic material and viral proteins (him having notes, but all of us will have them at the end of class)
*Making more viral DNA/RNA
DNA viruses use what enzyme?
DNA-dependent RNA Polymerase (DdRP)
RNA viruses use what enzyme?
RNA-dependent RNA Polymerase (RdRP)
Retro viruses use what enzyme?
Reverse Transcriptase (RT)
Early synthesis
Involves making the machinery needed to replicate the genome and viral proteins
Late synthesis
Actually copying the genome and making the structural protein
Assembly
Consists of the viral genomic material and viral proteins being put together to make a new virus (packing your stuff back up); this step can involve the assembly of hundreds or thousands of new virus particles
Release
Release of new viruses can occur via budding, exocytosis, or cellular lysis (leaving classroom); opposites of penetration
Lytic Cycle
active infection, virus is being produced and released, cell function is being disrupted, cell lysis/destruction may occur
Lysogenic Cycle
latent infection, viral genomic material inserts itself into the host chromosome, replicates itself when the host cell replicates, may become active again during times of stress
*Forms provirus: results in replication of viral genomic material
Example of Latent Viruses
Herpes Family (HSV-1, HSV-2, VZV, EBV, CMV) and HIV
