4.1) Hyperlipidaemia

Question 1

What is hyperlipidaemia?

Answer 1

Elevated plasma LDL/triglyceride levels???????????

Question 2

What is the correlation with cholesterol and CVD risk?

Answer 2

Increased cholesterol levels correlate with an increased risk of a cardiovascular event (Q risk)

Question 3

What is the first-line treatment of high cholesterol?

Answer 3

Statins

Question 4

At what level of Q risk are statins prescribed?

Answer 4

Greater than 10% Q risk

Question 5

What is the mechanism of action of statins?

Answer 5

Competitive inhibition of HMG-CoA reductase— rate controlling enzyme in HMG-CoA to mevalonate pathway

Question 6

Give examples of Statins

Answer 6

Simvastatin, Atorvastatin