4.05b Small and Large Intestine II

Question 1

Most common location and clinical feature of JUVENILE POLYP

Answer 1

Location: rectum

Clinical feature: rectal bleeding

Question 2

Age of children affected by JUVENILE POLYP? PEUTZ-JEGHER POLYP?

Answer 2

Juvenile polyp: <5 y/o

Peutz-Jegher poly: 10-15 y/o

Question 3

Mutation seen in PEUTZ-JEGHER POLYP

Answer 3

Germline heterozygous loss of function mutation of the STK11 gene

Question 4

Function of STK11 gene

Answer 4

Tumor suppression

Brake on growth and anabolic metabolism

Question 5

Most common location of PEUTZ-JEGHER POLYP

Answer 5

Small intestine

Question 6

Described SERRATED ADENOMA

Answer 6

Serrated architecture (full length of glands)
(+) malignant potential
lateral growth and crypt dilatation

Question 7

Differentiate INTERNAL and EXTERNAL HEMORRHOIDS

Answer 7

Internal: rectal or transitional epithelium; superior hemorrhoidal plexus within the distal ileum

External: stratified squamous epithelim; inferior hemorrhoidal plexus below anorectal line

Question 8

Diagnosis of ACUTE APPENDICITIS requires neutrophilic infiltration of ________.

Answer 8

Muscularis propria